Analysis Of Drug Metformin : A Disorder Of The Endocrine System

Diabetes is a disease where the body is unable to produce or use insulin effectively. Insulin is needed for proper storage and use of carbohydrates. Without it, blood sugar levels can become too high or too low, resulting in a diabetic emergency. It affects about 7.8% of the population. The incidence of diabetes is known to increase with age. It’s the leading cause of end-stage renal disease in the US, and is the primary cause of blindness and foot and leg amputation. It is known to cause neuropathy in up to 70% of diabetic patients. Individuals with diabetes are twice as likely to develop cardiovascular disease. There are two types of diabetes: Type 1 and Type 2.

Type 2 Diabetes is a disease that is found in a variety of age groups around the world. This disease is growing at a rapid rate and it is impacting the health of this generation and future generations to come. Diabetes is a disease that impairs the body’s ability to produce or respond to the insulin hormone produced by the pancreas. The insulin allows for the glucose to be effectively used as energy throughout the body. Diabetes causes carbohydrates to be abnormally digested, which can raise blood glucose levels. This means that the glucose is not being taken up by the cells that need it. The cells cannot take up the excess glucose that has accumulated in the blood, so it is excreted through the urine. This can lead to problems with the kidneys, central nervous system, heart, and eyes because high blood glucose can damage the blood vessels of these organs. This diseased is managed by adopting a diet low in fat and high in fiber, increasing physical activity, losing excess weight, and not smoking. If this

Uncontrolled diabetes can affect nearly every organ of the body; of which, heart disease and kidney failure are most commonly impacted. Known as diabetes mellitus, a collective term for various blood abnormalities, the term diabetes refers to either a scarcity of insulin in the body or the body’s inability to accept insulin. Though the symptoms of diabetes are manageable, many are unaware as to having it. According to the CDC report “2011 Diabetes Fact Sheet,” approximately 6 million people in the United States have undiagnosed diabetes. Undetected, diabetes can become deadly. In a recent World Health Organization report “Diabetes Action Now: An Initiative of the World Health Organization and the International Diabetes Federation,” it

Diabetes mellitus (DM) is a pandemic that affects millions of people. The growth rate of unrecognized pre-diabetes in America is expected to rise up to 52% by 2020 (Lorenzo, 2013). As the prevalence of diabetes increases, so will the complications and burden of the disease. One of the leading causes for cardiovascular disease, renal failure, nontraumatic lower limb amputations, stroke, and new cases of blindness is DM (Lorenzo, 2013).

Type 1 diabetes involves insufficient or no release of the hormone insulin by the pancreas and therefore requires daily insulin therapy while Type 2 diabetes results from either insufficient release of insulin or general inability of insulin to act on certain body cells, such as muscle cells and may or may not require insulin therapy.

Diabetes is a disease that affects the body’s ability to produce or use insulin. It is a precursor to numerous other diseases, which can quickly deteriorate patient’s health if

Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.

There are many types of diabetes. The two I will be discussing are type 1 and type 2. Type 1 generally affects young people and requires treatment with insulin. Five to ten percent of Americans with diabetes have this type. People with type 1 diabetes do not produce insulin and need regular shots of it to keep their blood glucose levels normal. People who are at risk for type 1 are those who have a family history of the disease,

Diabetes is a very common chronic medial disorder and expected to be a big medical challenge of the twenty first century (Clark, 2004). It is a condition, in which the glucose level in the blood becomes so high that the body is unable to utilize it properly. This long-term condition results when the pancreas of the victim is either not able to produce enough insulin (sometimes even cannot produce any insulin) or the insulin produced cannot work properly. Diabetes is divided into two main types: Type 1 and Type 2. Type 1, also known as insulin dependent diabetes milletus (Masharani, 2008) cannot be prevent while Type 2 can be prevented but if the patient is at pre-diabetes stage.

Diabetes mellitus type 2, also know as type 2 Diabetes or noninsulin dependent diabetes, is a disease that effects the body systemically. Type 2 diabetes is a disorder in which cells become resistant to insulin and can no longer bind it properly to reduce blood sugar. The result of this is elevated glucose levels in the circulating blood that leads to endothelial injury in all regions of the body. Primary damages occur in the kidneys, cardiovascular, and digestive systems. According to “Annual Number of New Cases of Diagnosed Diabetes Among Adults” (2015), the overall incidence of type 2 diabetes was approximately 1.4 million new cases. From previous years this number has decreased; however, it can be further lowered with proper education, change in the Western diet, and increase in physical activity. In 2012 approximately 27.7 million Americans were living with Type 2 diabetes. The cumulative cost of care for American diabetes patients was 245 billion dollars, which encompasses medical treatment cost and the patients’ inability to work, ultimately resulting in decreased personal production (“Statistics About Diabetes”, n.d.). As exemplified by the National Institutes for Health (2015), “Diabetes is a lifelong disease and there is no cure.” Even though no cure is present, lifestyle modifications such as diet and exercise, play a role in self-regulation of blood glucose levels.

According to The American Diabetes Association, “Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels” (p.1).

Diabetes is a metabolic disorder in which energy cannot be obtained from the body through normal mechanisms of action. Insulin is required to assist in moving glucose across cell membranes. There are two types of diabetes. Type one, which is characterized by the pancreas no longer having the ability to make insulin, and Type two, which is characterized by the resistance of the tissue receptors of the body to insulin. Diabetes is sometimes called “The Silent Killer,” as it has significant rates of illness and mortality. There is a large correlation between diabetes and cardiovascular disease, end-stage renal disease, amputations, and blindness (Gulanick, Myers 2014).

Diabetes is a major problem in our society today. Many people have heard about the disease; however, they do not know too much about its complications. Diabetes is a chronic, progressive and lifelong condition that affects the body’s ability to use the energy found in food (WebMD, 2016). Many new cases are confirmed every year and unfortunately, many go undiagnosed for years. Diabetes is a serious disease and need to be taking seriously. The disease can lead to many other health problems such as blindness, nerve damage and kidney diseases. The more the community understand and made aware of the seriousness of the disease, the better it can be control and or prevented.

Diabetes Mellitus is “a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. It is a disease which is caused by the insufficient insulin secretion or decrease in the peripheral effects of insulin. It is a serious problem in terms of morbidity and mortality. The hyperglycemia is associated with long term damage, dysfunction and failure of various organs especially the eyes, kidneys, nerves, heart and blood vessels. It’s associated with many complications which includes blindness of the eyes and amputations of the extremities. It is also associated with neuropathy, retinopathy, and cardiovascular diseases which lead to mortalities.

Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.