Desmoplastic Ameloblastoma Case Study

This cancer is a bone cancer that attack the bones, especially large bones. This cancer is named osteogenic sarcoma(Osteosarcoma) for medical term (“Osteosarcoma”, n.d.). Osteosarcoma mostly affects people under 25 years old, and it can affect old people but it is really rare(“Osteosarcoma: An Introduction.”, 2012). When this cancer attacks, it grows bones, and any type of bone (“Bone cancer”,2013). This cancer is an ancient disease that we started to recognize in 1805. Most of the symptoms are on the bones (“Bone cancer”,2013). It also is not contagious so its not passed from person to person like other diseases.

Osteosarcoma is an ancient disease that still has some mystery behind it. Osteosarcoma is a type of cancer that starts in the bones. It is also the most common type of bone cancer, and makes up 65% of all bone cancer. However, it is a very rare cancer and has fewer than 20,000 cases per year in The USA. The cells that form an osteosarcoma make bone matrix, similar to osteoblasts. However, the bone matrix of an osteosarcoma is not as strong as a bone matrix from an osteoblast, and therefore is not as strong as normal bones. The most common age group affected by osteosarcoma is children and young adults. However, osteosarcoma can occur at any age. Osteosarcoma is most commonly found in areas of the bone that grow quickly, which is why children are more likely to get this type of cancer. The most common place to find osteosarcoma is the end of long bones, especially in the knee, distal femur, and proximal tibia. The proximal humerus is typically the most common site. The treatments of

Osteosarcoma(OS) is a primary malignant tumor of bone which is characterized by the formation of osteoid tissue. Although it is the most common malignancy of long bones after multiple myeloma [2], it is a relatively rarer entity in the craniofacial region. About 6% of Oss arise in the jaws .The estimated incidence of the new cases of Jaw OS (JOS) per year is 0 .07 in 100,000. (1) The etiology of OS is unknown, but some risk factors such as a previous history of ionizing radiation, alkylating agent, retinoblastoma and benign bone lesions such as paget disease and fibro osseous dysplasia have been associated with the development of head and neck OS.(2-4) JOS occur with a peak in the third through fifth decades of life. The mean age is

by methods of removing or by means of chemotherapy. Expelling all traces and structures of the growth

Propelled malignancy is growth that has spread to far off parts of your body. This can incorporate your liver, brain or bones. Treatment relies on upon your general wellbeing and how best in class the growth is. It might be conceivable to hold the tumor under control by surgery or chemotherapy. Radiotherapy and chemotherapy can both help control side effects by contracting a disease with the goal that it doesn't bring about weight and torment and moderates its development. This is called palliative treatment.

It is well known that the highest incidence of osteosarcoma is found in children during early adolescence between the ages of 10 and 14; and in adults older than 65 (Langhorne et al, 2007). There is a higher incidence in children who are tall for their age (Cripe, 2013). Development of osteosarcoma in this age group, may suggest a direct correlation of rapid bone growth with the development of bone tumors (Wang, Chintagumpala, Gebhardt 2013). The risk of developing osteosarcoma during middle age decreases; however, increases again in older adults who have chronic bone conditions or disease (Wang et al, 2013). Osteosarcoma is found more often in males than females and in African Americans versus Caucasian persons (Cripe, 2013). People who have received direct ionizing radiation therapy for the treatment of other cancers may have a higher risk of developing a secondary osteosarcoma (Wang et al, 2013). Higher doses of radiation therapy and the age at which radiation treatment was received have also been associated with increased incidences (Wang et al, 2013). There are genetic syndromes that are associated with higher risk for developing osteosarcoma (Cripe, 2013). These genetic syndromes include: Retinoblastoma, Li-Fraumeni syndrome, Rothmund-Thompson syndrome, and Bloom and Werner syndrome (Langhorne et al, 2007). Persons who have chronic, non-malignant bone diseases such as Paget Disease are also at higher risk of developing osteosarcoma (Wang et al,

There are 206 bones in the adult human skeleton; these bones relate to movement, posture, and protect internal organs (American society of Clinical Oncology, 2012).Bones connect to bones with ligaments and are covered and protected by cartilage (American Society of Clinical Oncology, 2012).Cancer of the bone is rare but is caused by normal bone marrow and tissues inside the bone that change and form tumors(American Society of Clinical Oncology, 2012). The tumor happens in the bone and is benign it does not spread (American Society of Clinical Oncology, 2012). The benign tumor can press against surrounding tissues and weaken the bone it it grows big enough (American Society of Clinical Oncology, 2012). Malignant bone tumors break the surrounding tissue and cortex, hard covering of the bone (American Society of Clinical Oncology, 2012). The tumor can then get into the bloodstream and spread all over the body (American Society of Clinical Oncology, 2012). Osteosarcoma and ewing sarcoma are the two most common type of bone cancer (American Society of Clinical Oncology, 2012). Chondrosarcoma is more common in adults and is cancer of the cartilage (American Society of Clinical Oncology, 2012). The last type of bone cancer is chordoma which usually starts in the lower spinal cord (American Society of Clinical Oncology, 2012). Ewing sarcoma is a type of bone cancer that affects the hip, rib, and middle of bone most often (National Cancer Institution, 2015). Ewing

The patient went total mastectomy, grossly the growth measured 3.5x3.0x3.0 cm. The cut surface revealed a circumscribed, predominantly solid gritty tumor with minute cystic spaces along with calcification. Routine processing was done and stained with Hematoxylin and Eosin. Microscopic findings shows heterogeneous tumor showing glandular component comprises of proliferation of atypical spindle cells along with osseous metaplasia (Fig 1,2,3). The glandular component consisted of scattered small glands, elongated tubules and cell nests showing low to moderate grade atypia. At that time differential diagnosis of metaplastic carcinoma with osseous differentiation and mesenchymal tumor of breast with heterogonous osseous differentiation was made.

As these tumours are largely benign the tumour may just be monitored with regular MRI’s (Marzo, Zender & Leonetti, 2009). Surgical removal is considered when there is gross facial weakness (Marzo, Zender & Leonetti, 2009).

The asymptomatic nature of the lesion means that the presentation is late in most patients. Local recurrence is a problem with this tumor,

Bone cancer is defined as the uncontrolled growth of bone cells. The first recognizable symptoms are pain and tenderness in the bone. Other common signs include decreased mobility of a joint, fatigue, as well as anemia. Bone tumors are a clear indicator of bone cancer, however, they often go unnoticed until significant pain or injury has been acquired as a result. Apart from tumors, the symptoms of bone cancer are indecisive and can pertain to a number of medical conditions. This condition cannot be self-diagnosed, but only determined through further inspection by a doctor. (Viswanatha, 2011).

Diagnosis: The clinical significance of sclerosing adenosis lies in its mimicry of cancer. It may be confused with cancer on physical examination, by mammography, and at gross pathologic examination. Excisional biopsy and histologic examination are frequently necessary to exclude the diagnosis of cancer.

Sarcoma is a cancerous disease which develops from the soft tissues and or bone of the human body. Given this, sarcomas have been divided into two general groups: soft tissue sarcoma (STS) and osteosarcoma. STS may develop from soft tissues such as muscle, fat, nerves, blood vessels, or deep skin tissues. Sarcomas may spread throughout the body or may stay in one place. Furthermore, being affected by a cancerous disease causes proliferation of the connective tissue and or organs causing lumps to be formed. Given the status of the lumps they may be identified as various types. STS is a very rare cancer with approximation of about 1% among adults and 15% among the children. There has been no identification of definite causes but risk factors

The cancer I’m researching is bone cancer. Bone cancer is a mass of unusual cell growth in the bone. Most bone tumors aren’t cancers though. Bone cancer is a malignant (cancerous) tumor of the bone

General Features of MCC: MCC appears as a nontender red, firm dome shaped nodule that forms in the dermis and immediate subcutis. The tumor consists of densely packed nests or sheets of uniform undifferentiated cells showing the appearance of a so-called small round blue cell tumor. The cells have round to oval nuclei with vesicular to salt-and-pepper chromatin and inconspicuous nucleoli, and the cytoplasm is scant and ill-bordered. Some cases also have relatively irregularly shaped nuclei. The tumor usually has numerous mitotic figures and apoptotic bodies, and