Bone Cancer
Exploring the Symptoms, Treatment, Prevention, and Statistics of Chondrosarcoma and Osteosarcoma
Alexus Edwards & Gabrielle Newton
Ms. Knetter - A1
Ronald Wilson Reagan College Preparatory IB High School
Bone cancer is an uncommon disease that typically develops in the arm and leg bones (Mayo Clinic, 2015). Every year, there is an estimated 2,970 diagnoses made in the United States between all ages and genders (Cancer.net, 2014). The two most common types are osteosarcoma and chondrosarcoma, both of which share similar symptoms, treatment options, and survival rates.
Bone cancer is defined as the uncontrolled growth of bone cells. The first recognizable symptoms are pain and tenderness in the bone. Other common signs include decreased mobility of a joint, fatigue, as well as anemia. Bone tumors are a clear indicator of bone cancer, however, they often go unnoticed until significant pain or injury has been acquired as a result. Apart from tumors, the symptoms of bone cancer are indecisive and can pertain to a number of medical conditions. This condition cannot be self-diagnosed, but only determined through further inspection by a doctor. (Viswanatha, 2011). There are two types of bone tumors: benign (non-cancerous and typically non-threatening) and malignant (cancerous and requiring medical attention). Such growths are seen in metastatic bone cancers, a type of cancer that does not originally start in the bones, but spreads to the bones from
On February 20, 2013, after interfering with an arrest, Mr. Paul was arrested by Officer Marsha Dennehey, a thirteen-year veteran police officer of the Ann Arbor Police Department. (R. at 1, 6, and 14). Officer Dennehey has experience in identifying and handling drunk drivers because Ann Arbor is a college town and “heavily target[s] drunk drivers.” (R. at 14). She is also trained in recognizing and avoiding excessive force, as she chose to take training seminars on it almost every year it has been offered. (R. at 31).
The bone is made up of combined bones, bone marrow. Bone marrow is found in the middle of the main bone and it has blood vessles.There is two types of bone marrow are the red and the yellow. This type of cancer my effect the red blood cells, white blood cells, and
Ewing’s Sarcoma comes in several different forms: Ewing sarcoma of bone, Extraosseous Ewing sarcoma, Peripheral Primitive Neuroectodermal tumor (pPNET), and Askin tumor. [3]The most prominent type is Ewing’s sarcoma is of the bone, having a high percentage of approximation 87
This assignment will focus on the issue of Risk Assessment with relation to falls in the home in the elderly population. It will discuss the relationship between the community healthcare team and the individual client, the government policies related to the topic, and the influences of health policy upon the provision of community care. The role of the community nurse in public health education and promotion will also be explored. The client, in this particular instance, is Mrs Pugh.
The name chondrosarcoma [pronounced “kahn-dro-sahr-cohm-ah”] is a derivative of the Italian prefix “condro-” meaning cartilage, and the Italian noun “sarcoma,” referring to the tumor creation process itself. The suffix, “sarcoma,” has Ancient Greek roots and actually signifies the tumor-growing process [“sarx” + “oma” meaning, “flesh process”]. Chondrosarcoma is a type of malignant tumor (often referred to as a cancer and is closely identified with bone cancer) that can sometimes spread to nearby tissues. Chondrosarcoma usually grows superficially on bone matter and exists in two types: primary and secondary. Primary CS is usually evident in children, while secondary CS is apparent in adults ranging in age from 30 to 70; however, the highest occurrence rate exists from ages 40 to 60. CS cases develop in women and men in a ratio of 150 to 100; this means that men are 33% more susceptible to being diagnosed with this type of cancer than women.
Osteosarcoma, deriving form primitive bone-forming mesenchymal cells, is the most common primary bone malignancy[1]. The incidence rates of osteosarcoma has a bimodal age distribution. It typically occurs during adolescence and has the second peak in older adulthood[2]. There is variability in location between age groups, but usually the osteosarcoma occurs most frequently in long bones. The etiology of osteosarcoma is currently being studied but still not well understood[3]. Several studies showed that age, gender and height are risk factors for osteosarcoma[4]. The overall survival (OS) of osteosarcoma has been improved significantly because of effective chemotherapy combination[5]. Studies showed that complete surgical resection with addition of chemotherapy has increased the 5-year OS to approximately 70%[5], but improvements in osteosarcoma survival during the last decade have been limited[6].
Fresh bone can form in response to cancer spread osteoblastic, grows abnormally and causes the bone to be weak and deformed (Fischer and Quinn, 2011).
Larger examples may necessitate resection and reconstruction with a bone graft (Mintz & Velez, 2007). Because of the presence of a fibrous capsule, the tumour typically easily comes out in one piece from its bony crypt during curettage (Slootweg, 1996, Waldron, 1993). This tendency to shell out in one or a few pieces clinically differentiates OF from FocOD. Microscopically, the presence of a fibrous capsule separating the tumour from adjacent bone can be a useful distinguishing feature (Waldron, 1993). Recurrence rate is highly variable according to different studies. Some authors claim it is very low or inexistent (Brannon & Fowler, 2001, Waldron, 1985), while others have reported a 12-28% recurrence rate (Eversole et al., 1985a, MacDonald-Jankowski, 2009b). Until now, no microscopic feature distinguishes the tumours that have a higher risk of recurrence (Eversole et al., 1985a). Long-term radiographic follow-up is therefore recommended for patients with OF. For cases with rapid growth, a tendency to recur, especially affecting children, a diagnosis of juvenile ossifying fibroma (JOF) should be considered. Hyperparathyroidism-jaw tumour syndrome, a rare autosomal dominant syndrome caused by mutations in the tumour suppressor gene HRPT2, should be suspected in patients presenting OF of the jaws, familial hyperparathyroidism, renal cysts and Wilms tumours (Chen et al.,
INTRODUCTION: Malignancy such as multiple myeloma and metastases to the bone, a common occurrence in advance-stage disease, may necessitate the use of bone–modifying agents such as anti-resorptive medications, including pamidronate and zolendronate (intravenous bisphosphonates), denosumab (humanised monoclonal antibody) and anti-angiogenics such as sunitinib (tyrosine kinase inhibitor) and bavacizumab (humanized monoclonal antibody). Medication-related osteonecrosis of the jaw is a well-known complication of bone modifying agents used in the prevention of skeletal-related events such as bone fracture, spinal cord compression, radiotherapy or surgery in patients with metastatic disease and patients with osteoporosis or osteopenia. The risk of developing MRONJ in patients treated for metastatic disease is higher compared to patients of osteoporosis. Steroids, tobacco, immunosuppressive therapy and comorbidities like diabetes mellitus have been associated with an increased risk for MRONJ.
Osteoclastomas are usually treated by removal through surgery. In some cases, the tumor may be located in an area too dangerous to perform
Osteosarcoma is the most common primary solid malignancy of bone, is defined by the presence of malignant mesenchymal cells that produce osteoid and/or immature bone. The number of osteosarcoma in adolescence is 8-11 million per year at age 15 -19. In contrast, the general population number is 2–3million per year . Males are affected 1:4 times more commonly than females
es. Cancer can begin in any type of bone tissue. Bones are made up of osteoid (hard or compact), cartilaginous (tough, flexible), and fibrous (threadlike) tissue, as well as elements of bone marrow (soft, spongy tissue in the center of most bones).
Arthur Miller’s proclaimed play Death of a Salesman is a portrait of the delousion life a salesman puts his family through. The Loman family consists of four notable characters. Linda is a devoted wife and mother to her husband and two sons. She is the most selfless character throughout this play. Biff and Happy are the two Loman brothers who are constantly looking for approval from their father, Willy.
There are a wide variety of cancers affecting people and their loved ones everyday such as breast, lung, brain, and skin cancer just to name a few. Bone cancer is a rare type of cancer not talked about quite as often, but it still affects a large number of people. It is important to learn about bone cancer and its many manifestations in order to make quicker diagnoses and hopefully move closer towards finding a cure.
Bone cancer is a disease that occurs on or inside a bone. Usually, bone cancer involves a tumor filled with abnormal cells that will occasionally appear on the exterior of the bone. Similar to other types of cancer, bone cancer can be life threatening. Doctors are not completely sure what causes cancer, but they continue the search to find an answer. There are five different types of bone cancer that can affect people from ages 10-60 years old. Bone cancer can occur in any bone in the body from the legs to the head. Unfortunately, symptoms of bone cancer are not always obvious. Most of the time, pain is the most apparent symptom. When recognizing symptoms at an early stage, doctors can complete testing and supply treatment to