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Microorganism Causes Diabetic Foot Disease

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Diabetic Foot Infections and Damage Caused by Microorganisms.
Diabetes is due to a deficit or malfunction of insulin in the organism. In diabetes type 1, β cells of the pancreas are unable to synthesize insulin, therefore the cells are unable to intake glucose. This type of diabetes is usually observed in children. In diabetes type 2, the most common, insulin is produced, but the cells of the organism are unable to recognize it. In both cases, the patient experiences three main symptoms: polyuria (need to urinate frequently), polydipsia (constant thirst), polyphagia (constant hunger). Long term complications of diabetes can affect the ear, the kidney, the skin, the brain, and the feet. The treatment of those complications especially those …show more content…

This can be superficial and remain in the soft tissues or it can be deep and get to the bones. Amputation is the only remedy at that stage. Studies have demonstrated that the factors causing diabetic foot infection are aerobic Gram positive cocci especially Staphylococcus aureus, methillin resistant strain (MRSA), and some streptococcus species (Warren and Lipsky, 2010). Treatments directed towards those pathogens are more likely to be successful than broad spectrum antibiotic treatments. However, Staphylococcus aureus and MRSA make diabetic foot infection treatment more difficult because they display a resistance to the …show more content…

This pathogen secretes an Mottola et al. demonstrated that staphylococcus aureus and other microorganisms growing on the biofilms are not as resistant when isolated (2016). When staphylococcus strains were grown separately and treated with distinct antimicrobial agents, their minimum inhibitory concentrations were lower than on biofilms. Pathogens growing on biofilms are able to resist 10 – 10,000 times the concentrations of antimicrobial drugs that would kill an isolated strain; those concentrations can also be lethal for human beings. Mottola et al.’s experiment also showed that the minimum biofilms inhibitory and eradication concentrations values of antibiotics acting against isolated MRSA were higher than the minimal inhibitory concentrations values. some antibiotics such as for isolated pathogens were about the same for most of the antimicrobial agents studied. Although some antimicrobial agents such as Clindamycin were able to inhibit biofilms, but could not eradicate them (2016). Thus, there might still be some risks of

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