The Effect Of Nanoparticles On Lung Cancer

ovarian carcinoma to overcome the adverse side effects[13]. The results showed that targeting the LHRH receptors by using the LHRH peptide based delivery system substantially enhanced the efficacy of the chemotherapy. The LHRH targeted delivery system also did not show in vivo pituitary toxicity in the human ovarian carcinoma xenografts. Herein, we report the PEG-LHRH peptide conjugated mTS-mPAE NPs for the targeted delivery of mTOR siRNA to the lung tumor cells, utilizing bioreducible cationic polymer

Abstract Many attempts were made to treat different kinds of cancer, the problem was the lack of specificity of anticancer drug towards cancer cells resulting in severe side effects, but with the new system for drug delivery system –the nanoparticles –this problem could be avoided. Nanoparticles are very small particles from 1 to 100 nm with different shapes and sizes made of variety of materials .Nanoparticles have many applications in different aspects especially medicine including therapy and

techniques on nanoparticles as carrier systems for the delivery of anticancer drug molecules. A plethora of nanoparticle drug delivery formulations have been tested for their target specificity. The drug delivery system of nanoparticles is designed in such a way that they are independent of their environments and selective at a biological site. Some key features of drug delivery systems include parameters such as molecular weight, pH, particulate size, ionic strength and

affected area it must treat. This method allows smaller amounts of drugs to enter the body and prevent severe side effects by reacting with unaffected parts of the body. These nanocapsules travel in the bloodstream and release the drugs once in close proximity to the affected area. The main focus for this application is to treat cancer, where the capsules can either identify and attach to cancer cells or a magnet worn by the patient can trigger the capsule once it reaches a specific place in the body. Risk-Benefit

Australia, with the cooperation of scientists named Elizabeth H. Blackburn and Coral W. Greider (Jabbari et al.). It can treat a form of skin cancer known as melanoma if “specific types of cells [are tagged to nanoparticles] . . . [The cells can be conjugated] to target agents designed to recognize cell-specific surface proteins” (Jabbari, et al.). Nanoparticles attached to ultraviolet (UV) substances such as zinc oxide and titanium oxide can be manufactured, and thus targeted to skin cell surface proteins

macrophages after their uptake of nanoparticles 77. When co-incubated with human glioma spheroids, nanoparticle-laden macrophages can migrate and filtrate in the tumor as usual 78. Furthermore, two-photon fluorescence microscopy of glioma spheroids showed that nanoparticle-laden macrophages can accumulate in necrotic sites. When irradiated with 810 nm laser light, the growth of glioma spheroid dramatically decreased compared with the control without of nanoparticle-loading. The efficacy of macrophage-AuNS-mediated

A nanoparticle is a microscopic particle with at least one dimension less than 100 nm. Nanoparticles exist in the natural world and are also created as a result of human activities. Because of their submicroscopic size, they have unique material characteristics, and manufactured nanoparticles may find practical applications in a variety of areas, including medicine, engineering, catalysis, and environmental remediation. (King, Jarvie, & Dobson, 2017) Application of Nanoparticles The nanoparticles

conjugates have become a fast developing field, with several polymer conjugates systems heading for clinical trials monthly. Results from these clinical trials have shown that the advantage of these systems far outweigh the parent drug indicating few side effects, easy drug administration, advanced therapeutic effectiveness and enhanced patient acceptance. Larson and Ghandehari (2012) indicate also that polymer-drug conjugates offer the opportunity for drug delivery in a controlled manner. In contributing

many diseases that bombard our world some are curable while others have been killing people for years. Cancer is a non-communicable and non-infectious disease that takes the lives of numerous people each year and is the second leading cause of death in the United States (after heart disease) (http://www.cdc.gov). According to Statistics, in United States alone 14.5 million people are affected by cancer every year of which 595,690 have terminal prognosis and are expected to die in 2016, which translates

In this study, the green chemistry approach was used for quick synthesis (within 30 seconds) of gold nanoparticles (AuNPs) by using the fruit extract of Limonia acidissima L. The study focused on the formation of Limonia acidissima L stabilized AuNPs without using any catalytic agent. The AuNPs was confirmed by observation of the surface plasmon resonance (SPR) band at 537 nm. On the surface of these capped AuNPs, epirubicin (EPI) was conjugated along with activated folic acid (FA) for targeted drug