I am writing this paper on the subject of bone cancer because I have had a couple instances of cancer in my family. My father died in his thirties from a rare form of lymphoma when I was eight years old and my maternal grandfather died from leukemia in his eighties when I was twenty-eight years old. The same grandfather had colon cancer in his mid-fifties. This resulted in surgery to remove most of his colon which lead to the use a colostomy bag for the remaining part of his life. I know that some forms of cancer are caused by a hereditary genetic mutation, and I have seen the devastating effects of cancer first hand. Therefore, in addition to regular medical examinations, I would like to be more informed about cancer in general. The scope of this paper will include: first a brief definition of what cancer is, followed by information about bone cancer, and conclude with a summary of this paper’s findings on bone cancer.
Cancer, also known as a malignant tumor, is a disease in which some cells in the body multiply uncontrollably leading to a mass of abnormal cells (“What is Cancer”).This is the result of damage to the DNA (deoxyribonucleic acid) of a normal healthy cell which causes the natural biological function of the cell behavior to become altered (Mandal). Normal cell behavior is directed by the DNA which regulates the growth and death of the cell among other things (Mandal). When a normal cell’s DNA is damaged, the cell tries to repair the DNA and if it is unable to
Throughout life, many individuals experience difficulties due to growing up in everyday life. While going in depth of the human life, it is discovered that there are many diseases and disorders that affect humans’ everyday functions. A very popular disease that has traumatically affected the human body is cancer. Cancer is a disease that spreads throughout your body in many ways. The purpose of cancer is to attach to a blood cell in your body and cause a plague within itself, causing the body to initially shut down and die. This disease contains many forms and have many causes to it. However its main goal is to destroy the human body.
This cancer is a bone cancer that attack the bones, especially large bones. This cancer is named osteogenic sarcoma(Osteosarcoma) for medical term (“Osteosarcoma”, n.d.). Osteosarcoma mostly affects people under 25 years old, and it can affect old people but it is really rare(“Osteosarcoma: An Introduction.”, 2012). When this cancer attacks, it grows bones, and any type of bone (“Bone cancer”,2013). This cancer is an ancient disease that we started to recognize in 1805. Most of the symptoms are on the bones (“Bone cancer”,2013). It also is not contagious so its not passed from person to person like other diseases.
Osteosarcoma is an ancient disease that still has some mystery behind it. Osteosarcoma is a type of cancer that starts in the bones. It is also the most common type of bone cancer, and makes up 65% of all bone cancer. However, it is a very rare cancer and has fewer than 20,000 cases per year in The USA. The cells that form an osteosarcoma make bone matrix, similar to osteoblasts. However, the bone matrix of an osteosarcoma is not as strong as a bone matrix from an osteoblast, and therefore is not as strong as normal bones. The most common age group affected by osteosarcoma is children and young adults. However, osteosarcoma can occur at any age. Osteosarcoma is most commonly found in areas of the bone that grow quickly, which is why children are more likely to get this type of cancer. The most common place to find osteosarcoma is the end of long bones, especially in the knee, distal femur, and proximal tibia. The proximal humerus is typically the most common site. The treatments of
Osteosarcoma(OS) is a primary malignant tumor of bone which is characterized by the formation of osteoid tissue. Although it is the most common malignancy of long bones after multiple myeloma [2], it is a relatively rarer entity in the craniofacial region. About 6% of Oss arise in the jaws .The estimated incidence of the new cases of Jaw OS (JOS) per year is 0 .07 in 100,000. (1) The etiology of OS is unknown, but some risk factors such as a previous history of ionizing radiation, alkylating agent, retinoblastoma and benign bone lesions such as paget disease and fibro osseous dysplasia have been associated with the development of head and neck OS.(2-4) JOS occur with a peak in the third through fifth decades of life. The mean age is
during adolescent growth, which could be why 80% of all osteosarcoma childhood cases occur in the lower long bones and at the time of puberty (Mirabello & Savage 5). The chances of a cell dividing uncontrollably are increased at a time of rapid cell growth when there is many more cells dividing that could go suddenly go uncontrolled, and therefore the answer of how osteosarcoma is ignited could lie in puberty. On the contrary, the answer may be found in a small gene that prevents osteosarcoma patients from responding well to the chemotherapy treatment.
There are 206 bones in the adult human skeleton; these bones relate to movement, posture, and protect internal organs (American society of Clinical Oncology, 2012).Bones connect to bones with ligaments and are covered and protected by cartilage (American Society of Clinical Oncology, 2012).Cancer of the bone is rare but is caused by normal bone marrow and tissues inside the bone that change and form tumors(American Society of Clinical Oncology, 2012). The tumor happens in the bone and is benign it does not spread (American Society of Clinical Oncology, 2012). The benign tumor can press against surrounding tissues and weaken the bone it it grows big enough (American Society of Clinical Oncology, 2012). Malignant bone tumors break the surrounding tissue and cortex, hard covering of the bone (American Society of Clinical Oncology, 2012). The tumor can then get into the bloodstream and spread all over the body (American Society of Clinical Oncology, 2012). Osteosarcoma and ewing sarcoma are the two most common type of bone cancer (American Society of Clinical Oncology, 2012). Chondrosarcoma is more common in adults and is cancer of the cartilage (American Society of Clinical Oncology, 2012). The last type of bone cancer is chordoma which usually starts in the lower spinal cord (American Society of Clinical Oncology, 2012). Ewing sarcoma is a type of bone cancer that affects the hip, rib, and middle of bone most often (National Cancer Institution, 2015). Ewing
Out of all bone cancers, Osteosarcoma is the most common type. It effects about 3% of children with cancer
Metastatic bone cancer is a result of primary tumour cell spread, through direct and local invasion, and vasculature or lymphatic circulation. It is a common feature in solid tumours formed in lungs, breasts, thyroid and prostate along with multiple myelomas and renal carcinomas. One of the major signs and symptoms for patients with bone metastases is localized pain, which is often difficult to control and can be quite sever. This paper will discuss the process of metastasis, the aetiology and pathophysiology of bone metastases, and the changes that occur within bone due to metastatic spread. It will outline bone metastases signs and symptoms, and discuss radiotherapy treatment options based on patient assessments, focussing
Osteosarcoma is a malignant cancer of the bone. It originates from connective tissue; hence the suffix “sarcoma”. It is the most common cancer found in the bone, but it is also very rare. Osteosarcoma is more common in males than females, and it is also found mostly in African-Americans. Like all cancer, the cause of osteosarcoma is unknown, but there are risk factors. There is an increased risk of osteosarcoma in people that have germline mutations in the retinoblastoma and tumor protein genes.
Bone cancer is defined as the uncontrolled growth of bone cells. The first recognizable symptoms are pain and tenderness in the bone. Other common signs include decreased mobility of a joint, fatigue, as well as anemia. Bone tumors are a clear indicator of bone cancer, however, they often go unnoticed until significant pain or injury has been acquired as a result. Apart from tumors, the symptoms of bone cancer are indecisive and can pertain to a number of medical conditions. This condition cannot be self-diagnosed, but only determined through further inspection by a doctor. (Viswanatha, 2011).
Treatments for bone cancer varies from the type of cancer it is, it's stage, and
The word cancer is credited to the Greek physician Hippocrates who is considered the “Father of Medicine.” Some of the earliest evidence of human bone cancer was found in mummies in ancient Egypt and it dates back to 1600 B.C. Cancer begins when the cells in your body start to grow out of control. There are many different types of cancer but they all start because of uncontrolled cells.
Cancer occurrs by the production of multiple mutations in a single cell that causes it to proliferate out of control. Cancer cells often different from their normal neighbors by a host of specific phenotypic changes, such as rapid division rate, invasion of new cellular territories, high metabolic rate, and altered shape. Some of those mutations may be transmitted from the parents through the germ line. Others arise de novo in the somatic cell lineage of a particular cell. Cancer-promoting mutations can be identified in a variety of ways. They can be cloned and studied to learn how they can be controlled.
Introduction: Cancer, which is also known as malignant tumor, is a big threat to the humans. As the development of medical science and technology, many terrible diseases in the history have been eradicated or controlled such as smallpox, cholera, and phthisis. But why cancer is still threatening human, making people suffering so much? The reason is that people still don’t know the mechanism of cell canceration.
Bone cancer is a disease that occurs on or inside a bone. Usually, bone cancer involves a tumor filled with abnormal cells that will occasionally appear on the exterior of the bone. Similar to other types of cancer, bone cancer can be life threatening. Doctors are not completely sure what causes cancer, but they continue the search to find an answer. There are five different types of bone cancer that can affect people from ages 10-60 years old. Bone cancer can occur in any bone in the body from the legs to the head. Unfortunately, symptoms of bone cancer are not always obvious. Most of the time, pain is the most apparent symptom. When recognizing symptoms at an early stage, doctors can complete testing and supply treatment to