. How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question
100%

Question 10

L Adipocytes store fat in phospholipid-coated droplets in the cytosol. The protein perilipin is also
ossociated with the surface of the lipid droplet. (a) Describe the likely structure of the perilipin
protein. (b) Explain how phosphorylation of perilipin could help expose the lipids in the droplet to
digestion by lipases.
6 A deficiency of a citric acid cycle enzyme in both mitochondria and the cytosol of some tissues (e.g.
blood lymphocytes) results in severe neurological abnormalities in newborns. The disease is
herocterized by excretion in the urine of abnormally large amounts of a-ketoglutarate, succinate, and
fumarate. What enzyme deficiency would lead to these symptoms?
7. Name the three enzymes that form the pyruvate dehydrogenase complex.
8 For each reaction listed below, indicate the appropriate enzyme(s) in the pyruvate dehydrogenase
complex and the relevant cofactor(s), if applicable.
9. Reaction
Enzyme
Cofactor
(a) Oxidative formation of an enzymatic disulfide bond
(b) Transfer of hydroxyethyl group bound to TPP
(c) Liberation of CO2
(d) Oxidation of dihydrolipoamide
(e) Formation
of acetyl-CoA
10. How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?
Transcribed Image Text:L Adipocytes store fat in phospholipid-coated droplets in the cytosol. The protein perilipin is also ossociated with the surface of the lipid droplet. (a) Describe the likely structure of the perilipin protein. (b) Explain how phosphorylation of perilipin could help expose the lipids in the droplet to digestion by lipases. 6 A deficiency of a citric acid cycle enzyme in both mitochondria and the cytosol of some tissues (e.g. blood lymphocytes) results in severe neurological abnormalities in newborns. The disease is herocterized by excretion in the urine of abnormally large amounts of a-ketoglutarate, succinate, and fumarate. What enzyme deficiency would lead to these symptoms? 7. Name the three enzymes that form the pyruvate dehydrogenase complex. 8 For each reaction listed below, indicate the appropriate enzyme(s) in the pyruvate dehydrogenase complex and the relevant cofactor(s), if applicable. 9. Reaction Enzyme Cofactor (a) Oxidative formation of an enzymatic disulfide bond (b) Transfer of hydroxyethyl group bound to TPP (c) Liberation of CO2 (d) Oxidation of dihydrolipoamide (e) Formation of acetyl-CoA 10. How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Medical terminologies
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON