2. The so-called hypervariable regions (HV1 and HV2)of the human mitochondrial genome are sometimesused in forensic analysis. They are two noncoding regions of the mitochondrial genome, each approximately 300 bp, that flank the origin of replication; thefunction of these DNA sequences is not well understood. However, these two regions of mtDNA showthe most variation (SNPs and InDels) among differentpeople. The DNA within HV1 and HV2 accumulatesmutations at ten times the rate of DNA sequences inthe nuclear genome.a. Under what circumstances would human mtDNAbe preferable over nuclear DNA for identifyingindividuals?b. What are the disadvantages of using mtDNA,relative to nuclear DNA, in order to identifyindividuals?
2. The so-called hypervariable regions (HV1 and HV2)
of the human mitochondrial genome are sometimes
used in
function of these DNA sequences is not well understood. However, these two regions of mtDNA show
the most variation (SNPs and InDels) among different
people. The DNA within HV1 and HV2 accumulates
mutations at ten times the rate of DNA sequences in
the nuclear genome.
a. Under what circumstances would human mtDNA
be preferable over nuclear DNA for identifying
individuals?
b. What are the disadvantages of using mtDNA,
relative to nuclear DNA, in order to identify
individuals?
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