A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B: in the mechanism.
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A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B: in the mechanism.
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- Which of the following biochemical conversions can be carried out by the least number of proteins? Assume proper metabolic conditions, abundance of cofactors, necessary accessory molecules, etc. 1 propionyl-CoA → 1 succinyl-CoA 1 palmitate (16:0) → 8 acetyl-CoA 1 acetyl-CoA + 7 malonyl-CoA → 1 palmitate (16:0) 1 palmitate (16:0) → 1 acetyl-CoA + 1 myristic acid (14:0) 1 acetyl-CoA → 1 succinate Please answer very soon will give rating surelyAcetly CoA can quickly enter the citric acid cyle by joining with a C4 compound and forming citrate. Meanwhile, GTP (or ATP) is generated using inorganic phosphate while succinyl CoA is converted to succinate. What is the main reason both acetly CoA and succinyl CoA can perform such work? a. Acetyl CoA and succinyl CoA both contain coenzyme A, which is a high-energy compound. b. Acetyl CoA and succinyl CoA both form an unstable thioester bond with coenzyme A. c. Acetyl CoA and succinyl CoA both bind with inorganic phosphate which is used to generate ATP (or GTP). d. Acetyl CoA and succinyl CoA both transiently form a covalent bond with the enzymes that catalyze the next reaction, pyruvate dehydrogenase and succinyl-CoA synthetase, respectively. e. Acetyl CoA and succinyl CoA use the energy collected from the electron transport chain.Which one of the following will function to inhibit CPT1? A.palmitoyl-CoA B.citrate C propionyl-CoA D.acetyl-CoA E malonyl-CoA
- If the w-carbon atom of a fatty acyl CoA molecule with a C18 chain is labeled with C14, how many rounds of β-oxidation are required to produce a radioactively labeled acetyl CoA? a. four b. five c. six d. seven e. eight f. nineComplete the following paragraph describing the fate of the second 14CO-acetyl-CoA molecule incorporated into the glyoxylate cycle. The glyoxylate produced in the isocitrate reaction combines with a (A.) 2nd molecule of oxoaloacetate, B.) 2nd molecule of succinate, C.)2nd molecule of acetyl coa) in the malate synthase reaction. Malate is (A.Chiral, B.diasteromeoic C.)Achiral) ; therefore, the oxaloacetate produced from glyoxylate will be labeled at (A.Either of carboxylate carbon B. specifically at methylene carbon C. Specifically at carbonyl carbon D. Specifically at carboxylate carbon bonded to methylene).The sources of the three (3) carbons in malonyl-Coa is/are: a. 1 C from C02 and 2 C from acetyl-CoA b. 1 C from HCO3- and 2 C from acetyl-CoA c. 1 C from biotin and 2 C from acetyl-CoA d. All three C from acetyl-CoA
- succinyl-COA synthetase will do which of the following: Select one: a. Fumarate is combined with water to become Malate b. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADH c. Succinate is oxidized to become fumarate forming FADH2 d. Citrate is rearranged to become Isocitrate e. Malate is oxidized to become oxaloacetate forming NADH f. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide g. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH h. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) i. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADHLooking at the structure of alpha linolenic acid, how many rounds of beta oxidation will occur to fully oxidize the fatty acid into acetyl CoA molecules? Please provide explanationsExplain why people with Medium-chain acyl-CoA dehydrogenase deficiency are advised to eat a diet rich in complex carbohydrates. How is this condition normally diagnosed?
- In the context of fatty acid oxidation to acetyl CoA, indicate whether each of the following substances is involved in (1) fatty acid activation, (2) fatty acid trans-port, or (3) b-oxidation pathway. More than one choice may be correct in a given situation. a. AMp b. FAD c. Acyl CoA d. H2OIf acetogens conserve energy using the Rnf complex, then whatis the purpose of the reductive CoA pathway?Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbonsis metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acidcycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitaminsare the coenzymes derived? (Hint: see Chapter 23.) COO− COO−CH2CH2methylmalonyl-CoA succinyl-CoA CH3CH2 SCoA