A SNP that results in loss of all catalytic activity of a drug-metabolizing enzyme is most likely to occur in the codon for which of the following amino acids? Valine Phenylalanine Why? Correct Answer: Aspartate
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A SNP that results in loss of all catalytic activity of a drug-
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- Azidothymidine is a Thymidine analog used to inhibit viral reverse transcriptase. Explain the application of this nucleoside analog as an antiviral drug and how it affects reverse transcription and therefore block the ability of the virus to hijack the host cellWhy are structural analogs of sugar molecules (such as Oseltamivir and zanamivir) effective in treatment of influenza-virus infection?In site-directed mutagenesis experiments of an enzyme, scientists altered an aspartate residue to glutamate, lysine, phenylalanine, or valine. Which substitution is expected to have the least effect on enzymatic acitivity? Group of answer choices Glutamate Valine Lysine Phenylalanine
- For the given mutation below,please write down the reverse mutation and any intragenic suppressor mutations for that mutation. Use the codon table for amino acids as reference. In this case, mutation means single letter change. Mutation: AGA -> AGC Arg codons: CGU, CGC, CGA, CGG,AGA,ACG Ser codons: UCU, UCC, UCA, UCG, AGU, AGC Character limit is 10 characters. Write down Reverse mutation sequence first and then intragenic suppressor mutation sequence. Write down the mutated sequence not the mutation.An individual carries a somatic mutation that changes a lysinecodon into a glutamic acid codon. Prior to acquiring this mutation,the individual had been exposed to UV light, proflavin, and5-bromouracil. Which of these three agents would be the mostlikely to have caused this somatic mutation? Explain your answer.Two possible point mutations are the substitution of lysine for leucine or the substitution of serine for threonine. Which is likely to be more serious and why?
- In studies of the amino acid sequence of wild-type and mutant forms of tryptophan synthetase in E. coli, the following changes have been observed: Determine a set of triplet codes in which only a single-nucleotide change produces each amino acid change.Which of the following lac operon genotypes would allow for functional versions of all the structural enzymes of the lac operon to be expressed constitutively even in the absence of lactose? Group of answer choices I+ O+ Z+ Y+ A+ I- O+ Z- Y- A- I+ OC Z+ Y+ A+ IS O+ Z+ Y+ A+ I+ O+ Z- Y+ A+Which of the following mutations is likely to cause the most dramatic mutant effects: Missense, nonsense, sense? Explain your answer.
- Why would a mutation in a somatic cell of a multicellular organism escape detection?Drug 1-Ivacaftor (VX-770): Ivacaftor is a potentiator that increases CFTR channel opening time. We know from cell culture studies that this increases chloride transport by as much as 50% from baseline and restores it closer to what would be expected in wild type CFTR. Basically, the drug increases CFTR activity by unlocking the gate that allows for the normal flow of salt and fluids. For which class of mutations do you think Ivacaftor will be most effective? Explain your choice.Which of the following has been directly associated with deficiencies in several genes, especially SNRNP? Leber's hereditary optic neuropathy Myotonic dystrophy Angelman syndrome Prader-Willi syndrome Fragile X syndrome