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An unknown ion is flowing out of a neuron, creating an inhibitory response. This unknown ion must...
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- You learned in this chapter that Na+/K+ active transport pumps in the plasma membrane of the axons are responsible for creating the imbalance between Na+ and K+ inside and outside of the neuron that produces the resting membrane potential. In early research studying the role of ions and the involvement of active transport of ions in neural signaling, investigators used the giant axon of a squid as a model. The diameter of a giant axon is far greater than that of a mammalian axon, which enabled researchers to isolate it easily and use it in in vitro experiments. In one early experiment, researchers investigated the active transport of Na+ out of the axon in response to the presence of cyanide. Experimentally they hooked up a section of axon to a syringe, immersed the axon in artificial seawater, introduced radioactive 22Na (as 22NaCl) into the axon, and then quantified the transport of 22Na out through the axons plasma membrane. The rate of 22Na transport out of the axon was determined by measuring the radioactivity released into the fluid sur- rounding the axon over a period of time. The Figure shows the results of the experiment. What is the effect of cyanide on Na1 transport out of the squid axon? How do the data show the effect? Source: P. C. Caldwell et al. 1960. The effects of injecting energy-rich phosphate compounds on the active transport of ions in the giant axons of Loligo. The Journal of Physiology 152:561590. Cengage Learning 2017List the ions that contribute to electrical signaling in neurons and what side of the neuron their concentration is highestFor a signal to be sent down an axon of a nerve cell, an action potential must be generated. This is done by.. Select one: a. G-protein coupled receptors bind ligand, a phosphorylation cascade occurs, this causes a change in charge of the membrane due to the addition of phosphates allowing Na+ channels to open. b. Ligand-gated K+ channels open, allowing K+ to rush out of the cell and depolarize that part of the membrane. This change in charge opens neighboring voltage-gated channels. c. Ligand-gated Na+ channels open, allowing Na+ to rush in. This then depolarizes that region of the membrane resulting in opening neighboring voltage-gated channels. d. Receptor tyrosine kinases have two Na+ molecules bind, this opens voltage-gated channels allowing the “signal” to pass down the axon.
- Which of the following is not correct about a second messenger system? A. The activating hormone interacts with a receptor site on the plasma membrane. B. The activating hormone activates an enzyme, most often adenylate cyclase C. Activated adenylate cyclase catalyzes the transformation of AMP to cyclic AMP D. Cyclic AMP causes the activation of protein kinase E. None of these are correct.When a signal molecule (hormone) binds at a G protein-coupled receptor, the G protein a. Binds with GTP b. Becomes deactivated c. Binds with cAMP d. Binds with a kinase e. Binds to the signal moleculeA drug binds to a receptor and causes an immediate change in the electrical signaling or excitability of that cell, without activating another signaling molecule. What type of receptor is this drug most likely binding to? G-protein coupled receptor (GPCR) Ligand-gated ion channel Enzyme-coupled receptor Intracellular receptor Voltage-gated ion channel
- When a signaling molecule binds with a receptor, (a) G proteins are inactivated (b) a third messenger is activated (c) cell signaling is terminated (d) cAMP is produced by the receptor (e) the receptor becomes activatedAn extracellular signaling molecule binds to cell surface receptor. This cell surface receptor changes shape and activates a trimeric G-protein. What kind of receptor is this? a) Ion-channel coupled receptor b) Receptor Tyrosine Kinase c) G-Protein coupled receptor d) All of the other answers are correct e) Enzyme-coupled receptorIf a person gets covid, which cell signaling route will be activated.
- what characteristic is not one attributed to a second messenger? a. Intracellular signaling molecule b. molecules that can easily pass across membrane bilayers. c. molecules that can act as allosteric effectors for signaling proteins. d. molecules that can be rapidly converted between active and inactive forms. e. molecules that are synthesized in response to receptor/signal interaction.Which of the following is NOT an example of communication that happens from one neuron to another neuron? A. Endocrine signaling (ex. hormones secreted into the blood stream travel and bind to receptors on dstant cells). B. Retrograde neurotransmission (ex.the dendrite releases a neuroactive substance that binds to receptors on the axon terminal of a presynaptic neuron). C. Electrical communication via propagation of action potential from one node of ranvier to the next node of ranvier. D. Volume transmission (ex. neuropeptides diffuse away from the synapse and bind to receptors on adjacent cells) E. Electrical communication through gap junctions.Maximal physiological response to an external stimuli typically occurs when ______ of the receptors are bound by its ligand. A. None of the answers are true. B. All of the answers are true. C. Only a fraction D. 100% E. Most F. at least 50% G. Ligand-bound receptors do not result in any detectable physiological responses.
