Arsenate (AsO43-) has been used as a poison since ancient times. It disturbs glycolysis by interfering with the phosphoglycerate kinase reaction.  How does arsenate interfere with that reaction in molecular terms, and why is this interference toxic to the cell?

Introduction to General, Organic and Biochemistry
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ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter23: Enzymes
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Arsenate (AsO43-) has been used as a poison since ancient times. It disturbs glycolysis by interfering with the phosphoglycerate kinase reaction.  How does arsenate interfere with that reaction in molecular terms, and why is this interference toxic to the cell?

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