As the most junior member of a lab, you are tasked with generating cell lines that accumulate DNA damage to investigate how random mutations affect transformation of cells into cancer cells. You decide to mutate proteins in the p53 pathway. Which three proteins would you mutate? Explain your reasoning.

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A: Although gene therapy is a newer concept that has yet to be completely investigated, it has been…

Q: Which of the following is an example of epigenetic modulation?       a)  Ionization-induced DNA…

A: Introduction  The physical structure of DNA is altered by epigenetic modifications. DNA methylation,…

Q: A geneticist uses a generic engineering approach to mutate the TATA-building protein (TBP) of a…

A: *The TBP is the gene that instruct for making a protein called the TATA box binding protein. *This…

Q: If you were to design an epigenetic experiment, how would you design one? Keep in mind a good…

A: Epigenetics is the gene-level alterations that affect the functioning of DNA without actually…

Q: Why are knockout mice called that?

A: Introduction There are several ways by which the expression of any gene can be silenced or stopped.…

Q: How does the effect of nonsense mutation differ from that of a frameshift mutation? Why?

A: Mutations are changes that occurs in the deoxyribonucleic acid (DNA) sequence, either due to…

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A: The classical inheritance is the type of inheritance pattern in which mendelian laws are followed…

Q: Complete Table 1, indicating how much (lots, little, none) of the above gene product would be made…

A:

Q: What is the difference between silencing genes by imprintingand silencing by epigenetic…

A: Genomic imprinting is a process of silencing genes by the process of DNA methylation. The…

Q: Which of the following is a correct statement about epigenetics? Group of answer choices Increased…

A: Genetic changes are associated with changes in the DNA sequences.

Q: CpG is an epigenetic term that means: Select one: a. The binding of cytosine with the following…

A: We know that, DNA is the genetic material of almost all living organisms. It is made up of monomers…

Q: What is the key difference between cis- and trans-epigenetic mechanisms for maintaining an…

A: Epigenetics is the branch of genetics that studies heritable traits that are not influenced by the…

Q: Transformation is a process in which bacteria take up new DNA released by dead cells and integrate…

A: When transcription is under positive control, this means that a protein known as an activator binds…

Q: CpG is an epigenetic term which means: Select one: a. The binding of cytosine with the following…

A: DNA is the genetic material of almost all living organisms. It is made up of monomers of…

Q: . In selecting target cells to receive a transferred gene in gene therapy in an adult person, what…

A: To cure some of the human diseases gene therapy can be given to the patient. Gene therapy is the…

Q: How would you explain gene expression? How is it that a particular genotype is actually expressed as…

A: The central dogma is the flow of information that is carried by a gene that is expressed in the form…

Q: What is the first step in quantifying the relative amounts of mRNA in different tissues? Would this…

A: Hello. Since you have posted multiple questions and not specified which question needs to be solved,…

Q: Do a few cells created by therapeutic cloning of your own somatic cells constitute life? If these…

A: Somatic cells are those cell which forms the whole body of an organisms, also known as the vegetal…

Q: What DNA chemical modification can change the expression level of a target gene without sequence…

A: Introduction Epigenetics refers to the heritable or non-heritable changes in gene expression,…

Q: What would be required to prove that a phenotype is caused by an epigenetic change?

A: Epigenetics: It is study of heritable changes / phenotypes which are caused due to no changes in…

Q: What protein does the P53 code for and why is it important?

A: Answer :- The TP53 quality gives guidelines to making a protein called growth protein p53 (or p53).…

Q: What are the requirements for normal cell division? What are the requirements for cancer cells…

A: Mutation is defined as an erroneous change within the gene sequence of an organism that leads to a…

Q: According to the multi-hit model, more than one mutation must occur in a cell for cancer to develop.…

A: A new multihit model of carcinogenesis is produced for use in assessing age-explicit disease rate…

Q: Which of the following is not a possible outcome of changing the epigenetic code? a) exposure of…

A: * Epigenetic code is an defining code in eukaryotic cells in which each cell consist specific…

Q: How many different explanations can you think of for the observation that the rate of mutation…

A: A mutation is a change in our DNA sequence that happens as a result of errors in DNA copying or…

Q: Epigenetic changes in gene regulation are caused by ________.     missing nucleotides or chromosomes…

A: Epigenetic  Epigenetic is a reversible change in the DNA which controls the expression of genes.

Q: Is RNA silencing an environmentally-induced epigenetic change? Explain.

A: The regulation of gene expression via alterations to DNA, RNA, or histone proteins is known as…

Q: What are epigenetic modifications? a. the addition of reversible changes to histone proteins and DNA…

A: Epigenetic mutation can be defined as abnormal methylation level that can result in aberrant gene…

Q: Complete Table 1, indicating how much (lots, little, none) of the above gene product would be made…

A: Transcription It is defined as the process of transcribing the segment of the DNA to the RNA, which…

Q: A disease is caused by having no functional protein produced from the KIP gene. An individual has…

A: The gene expression follow the rules of central dogma that involves production of the final product…

Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…

A:

Q: . What is DNA methylation? When we say that DNA methylation is heritable, what do we mean? How is it…

A: Gene regulation is the process through which the cells control the expression of genes. This is…

Q: Let’s suppose you were interested in developing drugs to preventepigenetic changes that may…

A: Genes are basic physical and functional unit of heredity. It is a part of DNA that has instruction…

Q: In order to manufacture insulin for patients with diabetes, scientists create recombinant DNA by…

A: Recombinant DNA technology is the method which scientists used to insert human gene into bacterial…

Q: Geneticists have been exploring ways to suppress the expression of the extra chromosome 21 in…

A: Chromosomes are a compact form of DNA wrapped around some proteins and are generally present in a…

Q: How do germ-line mutations differ from somatic mutations? Germ-line mutations are reversible, while…

A: Mutations are the random changes in the genome of organisms.

Q: If p63 can bind to the same promoter elements as p53, why would it be considered an inhibitor of…

A: Promoters are DNA sequences that function as a kind of "On" switch to start the biological process…

Q: How do I draw the sequence and explain the process for each step? Draw the sequence of molecular…

A: In the nucleus, the STAT dimers localise and bind to specific DNA targets and induce gene…

Q: What type of epigenetic changes are associated with cancer?

A: Epigenetic changes or modifications are important for maintenance of tissue specific gene…

Q: The study of Epigenetics includes which of the following? (Choose all that apply)

A: 1.The vertical transmission of histone modifications 3.How Histone acetylation affects gene…

Q: What is the rationale for synthesizing and rapidly degrading p53 protein in the cell?

A: P53 is a nuclear transcription factor with pro apoptotic function as 50% of human Kansas carries…

Q: DNA sequencing has provided data to indicate that cancer cells may contain tens of thousands of…

A: Cancer cells are defined as the cells that will divide relentlessly and continuously; thus, forming…

Q: Why do stem cells that have been damaged prefer apoptosis over repairing the genome?   a. Stem…

A: The correct option is b i.e. the repair machinery is not perfect and therefore prone to make…

Q: Possible genetic modifications that can cause epigenetic changes in gene expression include: A- all…

A: Before you are born, epigenetic alterations occur.Your cells all have the same genes, yet they look…

Q: ow does DNA methylation occur? What enzyme is involved in DNA methylation? What are the consequences…

A: Since you have multiple questions, am answering the first question for you, for the remaining…

Q: Why is it that every cell needs to contain the DNA for the entire body when only a few of its genes…

A: Every cell contains the DNA for the entire body but a few are expressed by its cell type. The…

Q: Which of the following mutations would not convert a proto-oncogene into an oncogene?     A…

A: There are about three genetic mechanisms which play role in activating the oncogenes in human…

Q: Can you think of two ways in which the function of p53 can be disrupted?

A: P53 is a tumor suppressor gene which normally restrains growth and mutation in this causes loss of…