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- BIOC 384 G Protein-Coupled Receptor (GPCR) Signaling Q.7.3: Glucagon and epinephrine both signal stress, which would be low blood glucose levels or acute danger, respectively. Describe the upstream signaling pathways that would be activated in liver cells if you were hungry from a long hike in Sabino Canyon and came across the biggest rattlesnake you had ever seen right in front of you on the trail.design solutions for treating COVID-19 based on your understanding of the signaling pathwaysPlease ASAp. Thanku You discover a new species of frog in extremely dark parts of the Amazon rain forest. You hypothesize that this frog detects light using a mechanism similar to mammals. If you are correct, which of the following types of drugs would interfere with vision in this frog? (can choose more than one choice) a. TRPC blocker b.TRMP5 blocker c. CNG channel blocker d.PDE(phosphodiestrase inhibitor)
- Present the comparison of pharmacokinetics vs pharmacodynamics. Why the identification of different types of receptors is so important for drug’s pharmacodymics?As1 You are using a cell-culture model to screen for agonists that you wish to develop for the clinic. What is a risk that must be considered if the response you are measuring in order to compare your potential drugs is a long way from the ligand-binding event in the cellular cascade?a. Why is there an adverse interaction between monoamine oxidase inhibitors (MAOIs) often given for psychological disorders and an epi pen? b. Epi pens deliver a fast, large dose of epinephrine and are used by people suffering severe allergic reactions. As an AR agonist, epinephrine plays no role in allergic reactions, so why is it used?
- Provide a diagram of the EPH RECEPTOR B2 (EPHB2) structure. Give bioinformatics structureThe dissociation equilibrium constant (Kd) is:_____ (select all that apply) Group of answer choices: Is a measure of ligand efficacy Typically equivalent to 1- Ka The concentration of ligand that gives maximal receptor occupancy The concentration of ligand that gives half-maximal receptor occupancy Measured in 1/M or M-1 Typically measured in mol/L or M A measure of the strength of a ligand - receptor binding reactionOne of the initial symptoms a person can have for COVID-19 is the lost of taste and smell. Give a potential mechanism, including which portion of the reflex arc is being impacted, of how COVID is able to have this impact. Use an online source to support your argument.
- pls help ASAP, thanks! “A receptor antagonist is used to?”(ii) Considering the entropic contributions to ligand-receptor binding discuss how the strength of ligand-receptor binding for the molecule below may be affected by changing the double bond (1) to a single bond and removal of the hydroxyl group (2)233. Which of the following statements is true about chemokines such as CXCL-8? A. They are powerful activators of inflammation b. They are mainly mediators of the antiviral response c. They are mediators of chemotaxis d. Directly stimulate the growth of immune system cells in the bone marrow