Which of the below statements are FALSE?I: Cholesterol synthesis is regulated by covalent modification of HMG-COA reductaseII: Inhibition of ACAT mediated increase in esterification of cholesterol estersIII: Transcriptional regulation of the LDL particle regulates cholesterol synthesisIV: Squalene is a cholesterol precursorV: All the carbons in cholesterol comes from acetyl-CoAO A. I, IIO B. II, VO C. II, IIO D.I, IV

Cholesterol synthesis: The synthesis of cholesterol takes place in all tissues. The major sites of…

Answered: Which of the below statements are…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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High levels of acetyl-CoA could be an indication of excess A. Arg, Glu, Ile B. Lys, Tyr, Trp C. Phe, Tyr, Ile D. Thr, Tyr, Ala
Which of the following statements concerning cholesterol regulation is true? (A) SREBP localizes to the ER when cellular cholesterol levels are low.(B) HMG CoA reductase degradation is inhibited when exogenous cholesterol is plentiful.(C) Binding of cholesterol to SREBP causes SREBP to move to the nucleus.(D) Low cellular energy triggers phosphorylation and inhibition of HMG CoA reductase.(E) SREBP binds to a sterol regulatory element in the HMG-CoA reductase gene promoter to decrease gene expression.
Which one of the following will function to inhibit CPT1? A.palmitoyl-CoA B.citrate C propionyl-CoA D.acetyl-CoA E malonyl-CoA
Statin drugs are used to treat hypercholesterolemia because they a. prevent cholesterol from inserting in plasma membranes b. prevent cholesterol ester formation c. inhibit HMG-CoA reductase d. stimulate HMG-CoA synthase
Malonyl-CoA synthesis A. releases CO2 B. is inhibited by citrate C. requires acyl carrier protein (ACP) D. requires ATP
Which of the following is NOT a fate of acetyl-CoA in mammals?a. Is used to synthesize cholesterolb. Is used to synthesize ketone bodiesc. Is used to synthesize fatty acidsd. Is used to synthesize malonyl-CoA that is in turn converted into alaninee. Is oxidized by citrate acid cyclef. All of above are fates of acetyl-CoA
Which of the following statements is falseconcerning acetyl CoA carboxylase (ACC)? ACC is more active when protomers condense to form polymers Palmitoyl CoA serves as a feedback inhibitor The source of carbons for ACC comes from the carbon skeletons of malate that is exported from the matrix of the mitochondria in the form of malate Binding of glucagon triggers cAMP production, which leads to inhibition of ACC
One example of a stage 1 reaction in the heterotrophic breakdown of food molecules is: A. the intracellular digestion of some amino acids into NH4+ and pyruvate B. the intramitochondrial digestion of fatty acids into carbon dioxide and water C. the extracellular digestion of triglycerides into fatty acids and glycerol D. the intramitochondrial digestion of pyruvate into carbon dioxide and water E. the intracellular digestion of glucose monomers into pyruvate
Which of the following describes the function of lipoprotein lipase? Select one: a. It catalyzes the synthesis of lipoproteins b. It helps recycle unused cholesterol by converting to bile salts c. It helps to transport VLDL's in the blood d. It cleaves fatty acids from chylomicrons e. It helps to increase concentration of "good cholesterol"
Which of the following transfers fatty acid from carnitine to CoA I.carnitine translocaseII.coenzyme-AIII.CPT-IIIV.CPT-I
If PFK is activated in the liver, which of the following statements would be false? a) There are high levels of fructose 2,6 bisphosphate b) PFK is in the R-state c) Glycolysis would be activated d) AMP levels are low e) Gluconeogenesis is inhibited in the liver
Which of the following statements about the "central role" of TCA is/are correct? a. Some metabolic intermediates of TCA are used as non-carbohydrate sources for gluconeogenesis. b. β-oxidation of lipids produces acetyl-CoA that can enter TCA. c. All metabolic intermediates in TCA are used in the biosynthesis of amino acids. d. Degraded amino acids are converted to metabolic intermediates of TCA, then to ketone bodies.

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