Busulfan is a cell cycle non-specific alkylating antineoplastic agent or simply a chemotherapy drug in use since 1959. Busulfan is far more cytotoxic than two molecules of methyl mesylate (CH3OSO2CH3) because it can crosslink DNA strands. Using 1,2-ethanedithiol as a model compound show the structure of the product formed in the following reaction, where two ends of 1,2-ethanedithiol are linked. CH3 -SH HS Busulfan 1,2-ethanedithiol
Busulfan is a cell cycle non-specific alkylating antineoplastic agent or simply a chemotherapy drug in use since 1959. Busulfan is far more cytotoxic than two molecules of methyl mesylate (CH3OSO2CH3) because it can crosslink DNA strands. Using 1,2-ethanedithiol as a model compound show the structure of the product formed in the following reaction, where two ends of 1,2-ethanedithiol are linked. CH3 -SH HS Busulfan 1,2-ethanedithiol
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section: Chapter Questions
Problem 18.70P
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