Consider the pyruvate carboxylase reaction, the first bypass step in gluconeogenesis: Pyruvate + CO₂ + ATP = Oxaloacetate + ADP + P₂ Equilibrium concentrations were measured as follows: [pyruvate] =0.451 mM [HCO;] -7.02 mM (note that pCO₂ is represented as [HCO;']) [ATP] = 0.375 mM [oxaloacetate] =0.671 mM [ADP] = 0.963 mM [P] = 11.0 mM a) From the above data, calculate Ke, for the pyruvate carboxylase reaction b) Calculate AG" for this reaction c) Calculate AG under the following conditions: • [pyruvate]- 1.24 mM • [HCO3] = 7.69 mM [ATP] = 1.4 mM [oxaloacetate] =0.001 mM • [ADP]=0.032 mM [P] = 10.0 mm
Consider the pyruvate carboxylase reaction, the first bypass step in gluconeogenesis: Pyruvate + CO₂ + ATP = Oxaloacetate + ADP + P₂ Equilibrium concentrations were measured as follows: [pyruvate] =0.451 mM [HCO;] -7.02 mM (note that pCO₂ is represented as [HCO;']) [ATP] = 0.375 mM [oxaloacetate] =0.671 mM [ADP] = 0.963 mM [P] = 11.0 mM a) From the above data, calculate Ke, for the pyruvate carboxylase reaction b) Calculate AG" for this reaction c) Calculate AG under the following conditions: • [pyruvate]- 1.24 mM • [HCO3] = 7.69 mM [ATP] = 1.4 mM [oxaloacetate] =0.001 mM • [ADP]=0.032 mM [P] = 10.0 mm
Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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