Dog coat color genetics is actually more complicated that what is described for the Labrador dog example in your textbook. One gene locus, the A locus, has a dominant allele (AS, which gives hairs that are solid black, and aw, which is agouti (a wolf-like gray). As you know, the B locus is responsible for the difference in color between black (B-) and brown or chocolate (bb) Labradors. You also know that Labrador dogs also come in a yellow coat color. a) Set up a simple cross or set of genetic crosses that falsify the idea of the 3 colors of Labrador dogs being due to a simple multiallelic series, with black dominant to brown which is dominant to yellow.

Dog coat color genetics is actually more complicated that what is described for the Labrador dog example in your textbook. One gene locus, the A locus, has a dominant allele (AS, which gives hairs that are solid black, and aw, which is agouti (a wolf-like gray). As you know, the B locus is responsible for the difference in color between black (B-) and brown or chocolate (bb) Labradors. You also know that Labrador dogs also come in a yellow coat color. a) Set up a simple cross or set of genetic crosses that falsify the idea of the 3 colors of Labrador dogs being due to a simple multiallelic series, with black dominant to brown which is dominant to yellow.

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Description: Dog coat color genetics is actually more complicated that what is described for the Labrador dog example in your textbook. One gene locus, the A locus, has a dominant allele (AS, which gives hairs that are solid black, and aw, which is agouti (a wolf

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 2QP: Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To...

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Dog coat color genetics is actually more complicated that what is described for the Labrador dog example in your textbook. One gene locus, the A locus, has a dominant allele (AS, which gives hairs that are solid black, and aw, which is agouti (a wolf-like gray). As you know, the B locus is responsible for the difference in color between black (B-) and brown or chocolate (bb) Labradors. You also know that Labrador dogs also come in a yellow coat color. A.) Most geneticists try the simplest genetic explanation first. Set up a simple cross or set of genetic crosses that falsify the idea of the 3 colors of Labrador dogs being due to a simple multiallelic series, with black dominant to brown which is dominant to yellow.
In mammals, albinism is caused by an autosomal allele that interferes with skin pigment. Early one morning on your way to genetics class, you observe that two normally pigmented javelina parents have an albino piglet. What are the genotypes of the parents? _________________________________ What is the probability that their next five offspring will be albino? __________________________ What is the probability that 3 of the next 7 offspring will be normally colored?______________________ Describe the process by which you would test these normally colored offspring to see if they carried the albinism gene. What are the expected ratios from that test? You want to develop a strain of albino javelina for commercial use (the other really white meat). Describe how you would go about developing that strain starting with the 2 parents and the one albino offspring.
Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?
Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?
The gene controlling ABO blood type and the gene underlying nail-patella syndrome are said to show linkage. What does that mean in terms of their relative locations in the genome? What does it mean in terms of how the two traits are inherited with respect to each other?
Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessive allele responsible for the disease is inherited in a simple Mendelian manner. For unknown reasons, the allele is more common in populations of Ashkenazi Jews of eastern Europe. A woman is planning to marry her first cousin, but the couple discovers that their shared grandfather’s sister died in infancy of Tay-Sachs disease.a. Draw the relevant parts of the pedigree, and show all the genotypes as completely as possible. b. What is the probability that the cousins’ first child will have Tay-Sachs disease, assuming that all people who marry into the family are homozygous normal?
A geneticist examines an ear of corn in which most kernels are yellow, but he finds a few kernels with purple spots, as shown here. Give a possible explanation for the appearance of the purple spots in these otherwise yellow kernels, accounting for the different sizes of the spots.
The pedigree pictured is of an extended family where a large percentage of family members develop colon cancer at an early age. In this family, individuals either get colon cancer before the age of 16, or they don’t get it at all. a) Based on the information you have been given, what evidence, if any, suggests an inherited contribution to the development of this disease? b) You take a medical history of all 33 people in the pedigree and discover that a large percentage drink a special coffee on a daily basis, while others do not. The individuals who do not drink coffee are I-1, II-2, II-4, II-9, III-7, III-13, IV-1, and IV-3. Could drinking this special coffee play a role in colon cancer? Explain.
A recessive maternal effect mutant in zebrafish, called ichabod, results in embryos lacking heads that are non-viable. You have been instructed to identify females that are homozygous for the ichabod mutant allele. At your disposal are a tank of wild-type fish (males and females), a tank of male and female parental fish that are all heterozygous for the ichabod mutant allele (ichabod/+), and a tank of F1 fish derived from a cross between a heterozygous male and heterozygous female (ichabod/+). Which of the following would be a way to identify females that are homozygous mutant, i.e. ichabod/ichabod? Select all answers that would work.
Albinism is a recessive trait in humans . A geneticist studies a series of families in which both parents havenormal pigmentation and at least one child has albinism. The geneticist reasons that both parents in these families must be heterozygotes and that albinism should appear in 14 of their children. To his surprise, the geneticist finds that the frequency of albinism among the children of these families is significantly greater than 14. Can you think of an explanation for the higher-than-expected frequency of albinism among these families?
1. Duchenne’s muscular dystrophy (DMD) is a devastating X-linked recessive disease that causes muscle wasting and is eventually fatal. Meredith’s brother Craig has DMD but Meredith is healthy. You may find it beneficial to draw the family pedigree. a) What is the simple probability (as a percentage) that Meredith is a carrier of a mutation causing DMD? b) Meredith herself has two healthy children, a boy and a girl. Is this anterior (ancestral) or posterior (modifying) information? c) If Meredith IS a carrier for DMD (i.e. scenario A is correct), what is the probability (as a percentage) of her having these two healthy children?
Albinism is a recessive trait in humans.A geneticist studies a series of families in which both parents have normal pigmentation and at least one child has albinism. The geneticist reasons that both parents in these families must be heterozygotes and that albinism should appear in 14 of their children. To his surprise, the geneticist finds that the frequency of albinism among the children of these families is significantly greater than 14. Can you think of an explanation for the higher-than-expected frequency of albinism among these families?