Morphine (give structure) and enkephelin (give structure) both are antagonists of the m opioid receptor. How is that possible?
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- What functional group interactions between the cate- cholamines and adrenoceptors are most likely? Which functional groups are considered pharmacophores of catecholamines?What is the dihydropyridine (DHP) receptor?What functional group interactions between the cate- cholamines and adrenoceptors are most likely?
- Using the cultured cells used in this experiment and described in the introduction, how would you approach determining the potency of an agonist to the D2 receptor?Where is the binding site location of enkephalins in the brainTo maximize the activity of an α4β2 nicotinic Achtylchcholine Receptor (nAChR), how many agonist binding sitea should be occupied?
- The following compounds exhibit little to no adrenergic receptor function. Consider what components of adrenaline and noradrenaline are necessary for their action as agonists in light of this knowledge. Explain your response. Assume that the pH of the body is 7.Why muscarinic receptor antagonists are different from adrenergic beta-2-receptor agonists. What is the major benefit of using adrenergic beta-2-receptor agonists?Catecholamines like epinephrine and norepinephrine among having many physiological effects like increased blood pressure, on a molecular level will also promote the breakdown of what?
- Enkephalins and endorphins are referred to as “nature’s opiates.” Explain this saying.compare the binding site locations in the brain for enkephalins and the prescription painkillers morphine and codeine.a. Why is there an adverse interaction between monoamine oxidase inhibitors (MAOIs) often given for psychological disorders and an epi pen? b. Epi pens deliver a fast, large dose of epinephrine and are used by people suffering severe allergic reactions. As an AR agonist, epinephrine plays no role in allergic reactions, so why is it used?
