Protein bound to internal Outer 1 μη Internal nuclear matrix nuclear nuclear filament membrane matrix Internal Inner nuclear Nucleolus matrix nuclear membrane Nuclear lamina - Nuclear pore Nuclear lamina (a) Proteins that form the nuclear matrix (b) Micrograph of nucleus with chromatin removed Gene 100 μπ Protein that Radial loop attaches an MAR to a filament 30-nm fiber a MAR a MAR Protein filament (c) Micrograph showing a close-up of nuclear matrix (d) Radial loop bound to a nuclear matrix filament FIGURE 10.14 Structure of the nuclear matrix. (a) This schematic drawing shows the arrangement of the matrix within a cell nucleus. The Gene Gene

Protein bound to internal Outer 1 μη Internal nuclear matrix nuclear nuclear filament membrane matrix Internal Inner nuclear Nucleolus matrix nuclear membrane Nuclear lamina - Nuclear pore Nuclear lamina (a) Proteins that form the nuclear matrix (b) Micrograph of nucleus with chromatin removed Gene 100 μπ Protein that Radial loop attaches an MAR to a filament 30-nm fiber a MAR a MAR Protein filament (c) Micrograph showing a close-up of nuclear matrix (d) Radial loop bound to a nuclear matrix filament FIGURE 10.14 Structure of the nuclear matrix. (a) This schematic drawing shows the arrangement of the matrix within a cell nucleus. The Gene Gene

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter29: Transcription And The Regulation Of Gene Expression

Section: Chapter Questions

Problem 13P

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3. Draw and describe the “beads on a string” structure of the chromatin.4. What are the proteins found in the structure found in your answer in question number 3?Briefly give the importance of these proteins.
What is the name given to the structure of the MTOC found near the cell membrane that provides a template for cilia assembly? a. kinetic bodyb. basal bodyc. kinetochored. basal centromere
Look at the two yeast colonies in Figure Q4–3. Eachof these colonies contains about 100,000 cells descendedfrom a single yeast cell, originally somewhere in the mid-dle of the clump. A white colony arises when the Ade2 geneis expressed from its normal chromosomal location. Whenthe Ade2 gene is moved to a location near a telomere, itis packed into heterochromatin and inactivated in mostcells, giving rise to colonies that are mostly red. In theselargely red colonies, white sectors fan out from the middleof the colony. In both the red and white sectors, the Ade2 gene is still located near telomeres. Explain why white sec-tors have formed near the rim of the red colony. Based onthe patterns observed, what can you conclude about thepropagation of the transcriptional state of the Ade2 genefrom mother to daughter cells in this experiment?
what are we looking at in part (b)? Is this an11-nm fiber, a 30-nm fiber, or a 300-nm fiber? Does this DNAcome from a cell during M phase or interphase?
Imagine protein X, destined to span theplasma membrane. Assume that the mRNA carrying the geneticmessage for protein X has already been translated by ribosomesin a cell culture. If you fractionate the cells (see Figure 6.4), inwhich fraction would you find protein X? Explain by describingits transit through the cell.
A solution of pure αβ-tubulin dimers is thought tonucleate microtubules by forming a linear protofilamentabout seven dimers in length. At that point, the probabili-ties that the next αβ-dimer will bind laterally or to the endof the protofilament are about equal. The critical eventfor microtubule formation is thought to be the first lateralassociation (Figure Q16–2). How does lateral associationpromote the subsequent rapid formation of a microtu-bule?
The key components of desmosomes are cadherins and. actin microfilaments intermediate filaments microtubules
IPSCs are nearly identical to human embryonic stem cells in terms of gene expression, but there may be other ways in which they are not equivalent. For example, the telomeres of IPSCs often vary in length, with many IPSCs cells having telomeres shorter than those of embryonic. How might shortened telomeres affect the life-span of IPSCs or of differentiated cells derived from them?
6) There is clear evidence that chromatin state is directly related to the ability of proteins to initiate gene transcription. Compare and contrast euchromatin to heterochromatin in the context of transcription. Specifically comment on DNA and protein interactions.
Let’s suppose you have isolated chromatin from some bizarreeukaryote with a linker region that is usually 300–350 bp inlength. The nucleosome structure is the same as in other eukaryotes.If you digested this eukaryotic organism’s chromatin with ahigh concentration of DNase I, what would be your expectedresults?
The cisternal space of ER is continuous with prenuclear space between the two membranes of the nuclear envelope and can communicate with the internals spaces of the Golgi complex and lysosome by means of _____________ that shuttle between these structures. Which of the following experimental observations would suggest that chromosomes move by polymerization of tubulin subunits?
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