Q.3 Give reason: a. Enols are considered as strong nucleophiles as compared to alkenes. b. Aldol reaction is nucleophilic addition while Claisen is substitution. C. a-protons of carbonyl compounds are acidic.
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A: a.
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A:
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A:
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A:
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A:
Q: β-Vetivone is isolated from vetiver, a perennial grass that yields a variety of compounds used in…
A: a.
Q: Devise a synthesis of each compound from aniline (C6H5NH2) as startingmaterial.
A:
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A: (a)
Q: Draw a stepwise mechanism that illustrates how both products are formed in the following reaction.
A:
Q: Draw a stepwise mechanism for the intramolecular Friedel–Crafts acylation of compound A to form B. B…
A: The stepwise mechanism is shown below,
Q: Devise a synthesis of attached compound from the given starting materials.You may also use organic…
A:
Q: The analgesic naproxen can be prepared by a stepwise reaction sequence from ester A. Using enolate…
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- Consider carbonyl compounds A–E drawn below. (a) Rank A–E in order of increasing stability. (b) Rank A–E in order of increasing amount of hydrate formed when treated with aqueous acid. (c) Which compound is most reactive in nucleophilic addition?Draw a stepwise mechanism for the attached reaction, which involves two Friedel–Crafts reactions. B was an intermediate in the synthesis of the antidepressant sertraline(a) Why are alkyl halides insoluble in water? (b) Why is Butan-l-ol optically inactive but Butan-2-ol is optically active? (c) Although chlorine is an electron withdrawing group, yet it is ortho-, Para- directing in electrophilic aromatic substitution reaction. Why?
- (−)-Hyoscyamine, an optically active drug used to treat gastrointestinal disorders, is isolated from Atropa belladonna, the deadly nightshade plant, by a basic aqueous extraction procedure. If too much base is used during isolation, optically inactive material is isolated. (a) Explain this result by drawing a stepwise mechanism. (b) Explain why littorine, an isomer isolated from the tailflower plant in Australia, can be obtained optically pure regardless of the amount of base used during isolation.A- What is the definition of acidity? B- Compare the acidity of ammonia and its aliphatic derivatives with of acidity pyrrole C- Melting points of pyrrole is higher than melting point of 1-methyl pyrrole explain your answer D- Why does pyrrole prefer electrophilic substitution reactions? E- Why Pyrrole is considered to be an aromatic compound ? F- Explain the Reimer-Tiemann reaction mechanism of heterocyclic compounds? G- Why pyridine is a weak base? explain your answer? H- Pyridine can react with electrophiles, electrophilic substitution ? explain your answer ? G- Explain the Diels–Alder reaction mechanism of heterocyclic compounds? I- From a-haloketone how can you prepared flowing compounds : Imidazole Oxazole Thiazole J- compared the acidity and basicity of Pyrazole and Imidazole with Pyrrole and Pyridine ?Devise a synthesis of attached compound from the indicated startingmaterial, organic compounds containing one or two carbons, and anyother required reagents
- What product is formed when a solution of A and B is treated with mild base? This reaction is the rst step in the synthesis of rosuvastatin (sold as a calcium salt under the trade name Crestor), a drug used to treat patients with high cholesterol.Explain the reaction for the formation of acetal and hemiacetal. Explain why N,N-disubstituted amide is less acidic than ester. Why only methyl ketone do undergoes haloform reaction. LDA is the base of choice for carbonyl compound to completely convert into enolate. Why?Devise a stepwise mechanism for the following reaction.
- One step in the synthesis of the antihistamine fexofenadine involves acid-catalyzed hydration of the triple bond in A. Draw a stepwise mechanism for this reaction and explain why only ketone B is formed.Which ester, C or D, is more reactive in nucleophilic acyl substitution?Explain your reasoning.Draw a stepwise mechanism for the attached Friedel–Crafts acylation