Remember that DNA viruses inactivate tumor suppressor genes resulting in cancer. In Burkitt’s lymphoma, how does translocation of c-myc result in its overexpression?
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Remember that DNA viruses inactivate tumor suppressor genes resulting in cancer.
In Burkitt’s lymphoma, how does translocation of c-myc result in its overexpression?
Translocation of c-myc occurs to one of the immunoglobulin foci. This leads to over expression of genes, some of them being tumour promoter sequences.
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Solved in 2 steps
- Explain why IC3 is able to stop cancerous cells from dividing ?Describe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.The head of the oncology divison of a large biotech company proposes to develop a therapeutic antibody to treat cancers with mutant B-Raf oncogene. Is this a good idea? Why or why not(limit 3-4 sentences)?
- Explain why many oncogenic viruses contain genes whose products interact with tumor-suppressor proteins.a.What would happen if IKKbeta did not phosphorylate IkappaB? b.Why is it so hard to make cytokine therapies? c.Why would you use the MyD88 independent pathway versus the MyD88 dependent pathway?Compare and contrast oncogenes versus tumor-suppressorgenes.
- ''In the cellular regulatory pathways that controlcell growth and proliferation, the products of oncogenesare stimulatory components and the products of tumorsuppressor genes are inhibitory components.'' 'Is this statement true? Explain why or why not.Cancer-promoting mutations are likely to have different effects on the activity of proteins encoded byproto-oncogenes than they do on proteins encodedby tumor-suppressor genes. Explain.One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses. What advantage would a virus gain by inactivating RB function in its host cell?