Suppose part of the amino acid sequence of a protein is N... Gly-Ala - Pro-Arg-Lys ...C. Which of the following amino acid sequences could result from a frameshift mutation (+1 or -1) in the part of the gene that encodes this sequence of amino acids? O O N... Gly- Ala-Asn - Ser - Leu ...C N...Ala-Ala-Arg-Pro - Lys...C N...Gly-Gly-Thr-Thr-Glu...C N... Gly-Ala-His-lle - Val ...C N... Gly-His-Thr - Met - Val ...C

Suppose part of the amino acid sequence of a protein is N... Gly-Ala - Pro-Arg-Lys ...C. Which of the following amino acid sequences could result from a frameshift mutation (+1 or -1) in the part of the gene that encodes this sequence of amino acids? O O N... Gly- Ala-Asn - Ser - Leu ...C N...Ala-Ala-Arg-Pro - Lys...C N...Gly-Gly-Thr-Thr-Glu...C N... Gly-Ala-His-lle - Val ...C N... Gly-His-Thr - Met - Val ...C

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 20QP: If an extra nucleotide is inserted in the first exon of the beta globin gene, what effect will it...

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The earlier that two genes arose from a duplicated gene, themore their nucleotide sequences can have diverged, which mayresult in amino acid differences in the protein products. (a) Basedon that premise, identify which two genes are most divergentfrom each other. What is the percent amino acid identity betweentheir polypeptides? (b) Using the same approach, identify whichtwo globin genes are the most recently duplicated. What is thepercent identity between them?
Suppose the codon sequence GCCAUUCAAGCGGAU has a single base pair mutation to GCCAUUCAAACgGAU. If the old protein sequence was Ala-Ile-Gln-Ala-Asp, what will be the new sequence encoded by the mutant gene? _________(Use the 3-letter amino acid abbreviations with hyphens and no spaces in between, i.e. Ser-Asn-Tyr-Le
If an Arg residue in a protein was replaced with either Lys or Glu amino acid, whichsubstitution would you expect to result in the greatest structural change and why?
If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense mutation cause a protein to be shorter, longer, or the same length as the normal 700 amino acid proteins? What would be the effect of a nonsense mutation? A sense mutation?
A particular protein has the amino acid sequenceN . . . Ala-Pro-His-Trp-Arg-Lys-Gly-Val-Thr . . . Cwithin its primary structure. A geneticist studyingmutations affecting this protein discovered that several of the mutants produced shortened protein molecules that terminated within this region. In one ofthem, the His became the terminal amino acid.a. What DNA single-base change(s) would cause theprotein to terminate at the His residue?b. What other potential sites do you see in the DNAsequence encoding this protein where mutation ofa single base pair would cause premature termination of translation?
. Geneticists interested in human hemoglobins havefound a very large number of mutant forms. Some ofthese mutant proteins are of normal size (but haveamino acid substitutions) while others are short, dueto deletions or nonsense mutations. The first extralong example was named Hb Constant Spring, inwhich the β-globin has all of its normal amino acidsplus several extra amino acids attached after thenormal C-terminal end of the protein. a. What is the most plausible explanation forits origin?b. Is it possible that Hb Constant Spring arose fromfailure to splice out an intron?c. Estimate how many extra amino acids mightbe added to the C terminal end of the mutantprotein
Once translated into proteins: (a) How many nucleotides are there? (b) How many codons are there? (c) How many amino acids?
The base sequence of which type of RNA is responsiblefor determining the order of amino acids in a protein?
Does every gene mutationcause alteration in the proteinthe gene normally codifies?
if mRNA has a codon sequence of 5'-UAG-3', it will encode: Ieucine, no amino acide, methionine, a mutation, or an anticodon?
How many amino acids will the mRNA sequence "AUG GAC CUG UCG UGA" produce?
If a mutation changes base triplet 1 from ATG to ATA, why will this not change the protein formed?