. Geneticists interested in human hemoglobins havefound a very large number of mutant forms. Some ofthese mutant proteins are of normal size (but haveamino acid substitutions) while others are short, dueto deletions or nonsense mutations. The first extralong example was named Hb Constant Spring, inwhich the β-globin has all of its normal amino acidsplus several extra amino acids attached after thenormal C-terminal end of the protein. a. What is the most plausible explanation forits origin?b. Is it possible that Hb Constant Spring arose fromfailure to splice out an intron?c. Estimate how many extra amino acids mightbe added to the C terminal end of the mutantprotein

Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN:9781305073951
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Chapter31: Animal Tissues And Organ Systems
Section: Chapter Questions
Problem 1CT: IPSCs are nearly identical to human embryonic stem cells in terms of gene expression, but there may...
icon
Related questions
Question

. Geneticists interested in human hemoglobins have
found a very large number of mutant forms. Some ofthese mutant proteins are of normal size (but have
amino acid substitutions) while others are short, due
to deletions or nonsense mutations. The first extralong example was named Hb Constant Spring, in
which the β-globin has all of its normal amino acids
plus several extra amino acids attached after the
normal C-terminal end of the protein.
a. What is the most plausible explanation for
its origin?
b. Is it possible that Hb Constant Spring arose from
failure to splice out an intron?
c. Estimate how many extra amino acids might
be added to the C terminal end of the mutant
protein

Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Types of cancer
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biology: The Unity and Diversity of Life (MindTap…
Biology: The Unity and Diversity of Life (MindTap…
Biology
ISBN:
9781305073951
Author:
Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:
Cengage Learning
Human Heredity: Principles and Issues (MindTap Co…
Human Heredity: Principles and Issues (MindTap Co…
Biology
ISBN:
9781305251052
Author:
Michael Cummings
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning