The lipid portion of a typical bilayer is about 30 Å thick.(a) Calculate the minimum number of residues in an a-helix required tospan this distance.(b) Calculate the minimum number of residues in a b-strand required tospan this distance.(c) Explain why a-helices are most commonly observed in transmembraneprotein sequences when the distance from one side of a membrane to theother can be spanned by significantly fewer amino acids in a b-strandconformation.(d) The epidermal growth factor receptor has a single transmembrane helix.Find it in this partial sequence:                . . . RGPKIPSIATGMVGALLLLVVALGIGILFMRRRH . . .

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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The lipid portion of a typical bilayer is about 30 Å thick.
(a) Calculate the minimum number of residues in an a-helix required to
span this distance.
(b) Calculate the minimum number of residues in a b-strand required to
span this distance.
(c) Explain why a-helices are most commonly observed in transmembrane
protein sequences when the distance from one side of a membrane to the
other can be spanned by significantly fewer amino acids in a b-strand
conformation.
(d) The epidermal growth factor receptor has a single transmembrane helix.
Find it in this partial sequence:
                . . . RGPKIPSIATGMVGALLLLVVALGIGILFMRRRH . . .

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