Trace the pathway of [14C]bicarbonate through gluconeogenesis. Use an asterisk to indicate the location of ¹4C in all intermediates and in the final gluconeogenesis product, glucose.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Trace the pathway of [14C]bicarbonate through gluconeogenesis. Use an asterisk to indicate the location of ¹4C in all
intermediates and in the final gluconeogenesis product, glucose.
HO-C
O-
=0
[¹C] Bicarbonate
CH₂OPO
H-C-OH
--OPO
O
1,3-Bisphospho-
glycerate
↑
-COO
-CH₂
TC=O
coo
Oxaloacetate
CH,OPO
H-C-OH
COO
↑
3-Phosphoglycerate
CH₂
C-OPO
-COO
Phosphoenolpyruvate
CH,OH
HC-OPO,
COO
2-Phosphoglycerate
Answer Bank
Transcribed Image Text:Trace the pathway of [14C]bicarbonate through gluconeogenesis. Use an asterisk to indicate the location of ¹4C in all intermediates and in the final gluconeogenesis product, glucose. HO-C O- =0 [¹C] Bicarbonate CH₂OPO H-C-OH --OPO O 1,3-Bisphospho- glycerate ↑ -COO -CH₂ TC=O coo Oxaloacetate CH,OPO H-C-OH COO ↑ 3-Phosphoglycerate CH₂ C-OPO -COO Phosphoenolpyruvate CH,OH HC-OPO, COO 2-Phosphoglycerate Answer Bank
1,3-Bisphospho-
glycerate
CH₂OPO
H C-OH
-H
Glyceraldehyde
3-phosphate
3-Phosphoglycerate
CH₂OPO
(0
-CH₂OH
Dihydroxyacetone
phosphate
20,POH,C CH,OPO
HOHC
FO
HO-L-C-OH
HH
Fructose 1,6-bisphosphate
2-Phosphoglycerate
H.
HIC OH
HO-C-H
H-C-OH
H-C1OH
CH,OH
Glucose
Transcribed Image Text:1,3-Bisphospho- glycerate CH₂OPO H C-OH -H Glyceraldehyde 3-phosphate 3-Phosphoglycerate CH₂OPO (0 -CH₂OH Dihydroxyacetone phosphate 20,POH,C CH,OPO HOHC FO HO-L-C-OH HH Fructose 1,6-bisphosphate 2-Phosphoglycerate H. HIC OH HO-C-H H-C-OH H-C1OH CH,OH Glucose
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