Tracing a disease gene through a family tree II II IV VI VII 1. Now the UDP doctors terial calcification due to as that she was not alone sters, and all of them had arents were unaffected. ne of these children had sted that the underlying ge and all of her siblings e that influences CD73 ather. A person with one both of a person's copies provides. The situation is unctional allele is domi- FIGURE 1-15 Family tree or pedigree showing the inheritance of the mutant gene causing arterial calcification due to deficiency of CD73 (ACDC). Squares are males, and circles are females. Horizontal lines connecting a male and female are matings. Vertical lines connect a mating pair to its offspring. Roman numerals designate generations; Arabic numerals designate individuals within generations. Half-filled squares or circles indicate an individual carrying one copy of the mutant gene. Filled squares or circles indicate an individual with two copies of the mutant gene and who have the ACDC disease. Either individual I-1 or l-2 must have =, only appears if an indi- carried the mutant gene, but which one carried it is uncertain as indicated by the "2". Blue arrow indicates Louise Benge. Red arrows show the path of the mutant gene through the generations. [Data from C. St. Hilaire et al, New England Journal of Medicine 364, 2011, 432-442] nistory and learned that velation fit well with the d and wife are close rela- that they will both have ir common ancestor and Idren Chldren with
Tracing a disease gene through a family tree II II IV VI VII 1. Now the UDP doctors terial calcification due to as that she was not alone sters, and all of them had arents were unaffected. ne of these children had sted that the underlying ge and all of her siblings e that influences CD73 ather. A person with one both of a person's copies provides. The situation is unctional allele is domi- FIGURE 1-15 Family tree or pedigree showing the inheritance of the mutant gene causing arterial calcification due to deficiency of CD73 (ACDC). Squares are males, and circles are females. Horizontal lines connecting a male and female are matings. Vertical lines connect a mating pair to its offspring. Roman numerals designate generations; Arabic numerals designate individuals within generations. Half-filled squares or circles indicate an individual carrying one copy of the mutant gene. Filled squares or circles indicate an individual with two copies of the mutant gene and who have the ACDC disease. Either individual I-1 or l-2 must have =, only appears if an indi- carried the mutant gene, but which one carried it is uncertain as indicated by the "2". Blue arrow indicates Louise Benge. Red arrows show the path of the mutant gene through the generations. [Data from C. St. Hilaire et al, New England Journal of Medicine 364, 2011, 432-442] nistory and learned that velation fit well with the d and wife are close rela- that they will both have ir common ancestor and Idren Chldren with
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter4: Pedigree Analysis In Human Genetics
Section: Chapter Questions
Problem 14QP: Analysis of Autosomal Recessive and Dominant Traits Huntington disease is a rare, fatal disease that...
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Question
Figure 1-15 shows the family tree, or pedigree, for Louise
Benge (Individual VI-1) who suffers from the disease
ACDC because she has two mutant copies of the CD73
gene. She has four siblings (VI-2, VI-3, VI-4, and VI-5)
who have this disease for the same reason. Do all of the
10 children of Louise and her siblings have the same
number of mutant copies of the CD73 gene, or might
this number be different for some of the 10 children?
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