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- The enzymes GICNAC phosphotrasnferase is a key enzyme involved in the transporting of proteins from the trans-Golgi to the lysozyme. In addition to the catalytic function of the enzyme that involves certain sugars, what is the second critical function of this enzyme? O It recognizes internal signal sequences found on lysozyme-targeted proteins. O It drives the binding of a phosphorylated GlcNac group onto a mannose residue. O It facilitates the reversible binding of specific proteins to the M6P receptor O In is essential for the recruitment of clathrin triskelions to the budding vesicle.Which of the following best describes the use of 2-deoxyglucose in allowing for cancer therapy? Elevates p53 levels directly to regulate glycolytic flux Blocks activation of HIF1transcriptional activation Diminishes lactate production by inhibiting lactate dehydrogenase to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Diminishes lactate export from the cell to allow increased levels of pyruvate to force the transport of pyruvate into the matrix and the function of the TCA cycle Competes with glucose for hexokinase, allowing inhibition of glycolytic flux, reducing ATP production.One signal may activate multiple downstream pathways cell. For example, insulin can bind the insulin receptor la receptor hyrosine kinosed to cause in a single in changes glucost metabolism & transport, and cell growth. Outline possible steps between activation of an insulin receptor and (A) Phosphorylation of a TF (transcription factor) by merek-p B) Syntheri) of PIPS. () Activation of Calcium - Calmodulin- dependent protein kinale. In some cells, Scaffold proteic • Phosphorylated MAPK may To Turn Off Pathway: a) Phosphate Б) марккк по E) Raj - GAP = GTPase Activating GTPase activity of
- Suppose that in the formation of phenylalanine hydroxylase mRNA, the exons of the pre-mRNA fail to splice together properly and the resulting enzyme is nonfunctional. This produces an accumulation of high levels of phenylalanine and other compounds, which causes neurological damage. What phenotype would be produced in the affected individual?Increased ROS levels are a hallmark for Alzheimer's Disease. This is accurately described by all but which of the following statements? ROS production is upregulated because of the activity of the enzyme NADPH oxidase Oxidative phosphorylation is increased, leading to enhanced ROS generation via the ETC Amyloid precursor protein is converted in higher amounts to the amyloid peptide facilitating greater amounts of aggregation BACE1 levels are transcriptionally increased via hypoxia inducible factor Mitochondrial pyruvate flux is reduced 00000Stimulation of map kinase can help regulate cell division and cell mass. the following effects of map kinase activation explains an increase in cell mass. Phosphorylation of RSK (kinase and the subsequent phosphorylation of S6 ribosomal subunit. Phosphorylation of myosin light chain Phosphorylation of glyceraldehyde dehydrogenase phosphorylation of histone H1 none of these
- When a trimeric G protein is activated by GPCR? The three subunit of the G protein remain tightly associated with each other; the GDP bound to the a subunit is phosphorylated to form bound GTP; it dissociates into a free B subunit and an ay subunit Options: hydrolyzed, cleaves, phosphorylate, dephosphorylates, folds, glycosates; gtp, gdp, cgmp, atp, adp, camp; cleaves, phosphorylation, dephosphorylation, unfolds, glcosylates, deglycosylate; leucine kinases, glycine kinase, Tyrosine kinases, valine kinase; triimetization, dimerization, monomerizationAutophagy is an évolutionary conserved catabolic process devoted to the degradation of intracellular components. Which of the following would you observe during autophagy? Select all that apply MTOR inhibition through phosphorylation and activation of TSC proteins MTOR activation and phosphorylation of downstream target proteins Increased expression of Rab7 which mediates lysosomal fusion Acute inflammatory responseWhat effect does binding of the IRF protein to the IRE in the mRNA encoding ferritin have on the production of ferritin? Briefly explain why this effect is observed.
- Overall RNA metabolism and proteins involved are regulated by ubiquitin signaling. Explain how ubiquitination plays role in maintaining certain levels of proteins needed by including the process of protein degradation, ubiquitination, any enzymes, proteasome, any ATP hydrolysis. PLEASE do not provide me with a super long answer. Short and to the point would be greatly appreciated!!!!!Describe the role of pH in regulating the interaction between mannose 6-phosphate and the M6P receptor. Why does a rise in endosomal pH lead to the secretion of newly synthesized lysosomal enzymes into the extracellular medium?Predict the location(s) (intracellular or extracelular) and a brief description of WHY based on your knowledge of the transport processes in the following constructs. Assume a start codon is present and include any proteolytic processing that would be likely. 1. A PTS1 C-term peroxisomal targeting seq added to C term of a normally secreted protein with usual N -terminal signal sequence 2. Adding of N-terminal mitochondrial targeting sequence to protein with internal nuclear localization seq. 3. Adding N-terminal signal sequence of secreted protein to N-terminus a mitochondria matrix protein precursor with mitochondrial targeting sequence still present