There can be more than one answer Vitamin D, thyroid hormone and prostaglandins are all steroid hormones that bind to type II receptors.Which of the following statements are correct about the mechanism of action of type II steroidhormone receptors?O When inactive, they exist in complex with heat shock proteins (Hsps) in the cytoplasmO Upon activation, they translocate to the nucleus and directly bind DNA as a transcription factorThey contain a DNA binding, a dimerization and an activation domainThey are always bound to DNA, but dependent on the presence of their ligand exist in complex with either acorepressor or coactivator

Hormones are the chemical messengers that are secreted by the glands. They play an important role in…

When inactive, they exist in complex with heat shock proteins (Hsps) in the cytoplasm Upon activation, they translocate to the nucleus and directly bind DNA as a transcription factor They contain a DNA binding, a dimerization and an activation domain They are always bound to DNA, but dependent on the presence of their ligand exist in complex with either a corepressor or coactivator

When inactive, they exist in complex with heat shock proteins (Hsps) in the cytoplasm Upon activation, they translocate to the nucleus and directly bind DNA as a transcription factor They contain a DNA binding, a dimerization and an activation domain They are always bound to DNA, but dependent on the presence of their ligand exist in complex with either a corepressor or coactivator

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

See similar textbooks

Similar questions

A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct? EGF signaling cascades would be active for longer in the cell. EGF signaling cascades would be active for a shorter period of time in the cell. EGF signaling cascades would not occur. EGF signaling would be unaffected.
A hormone molecule binds to a receptor on a cell membrane. It doesnt enter the cell; rather, the binding activates a second messenger inside the cell that triggers an amplified response to the hormonal signal. Is the signaling molecule a steroid or a nonsteroid hormone?
Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib? Signaling molecule binding, dimerization, and the downstream cellular response. Dimerization, and the downstream cellular response. The downstream cellular response. Phosphatase activity, dimerization, and the downsteam cellular response.
The two major types of cell-surface receptors that bind tohormone molecules are G-protein linked receptors and_____________________.
The transforming growth factory beta (TGF-b) family of hormones / growth factors are dimers and they interact with specific receptors. Which of the following statements about these receptors is correct? a) A receptor complex is formed from a type 1 and a type 2 receptor b) A receptor complex is formed between the ligand and the receptor c) This family interacts with a single serine- threonine kinase receptor d) The major receptor is intracellular e) The receptor is a G-protein receptor
Recently, a Gα q-coupled receptor was discovered that mediates at least some of the many activities of estrogen. At the time, this discovery generated considerable controversy, as it ran counter to what was then the understanding of how steroid hormone signaling worked. Which of the following observations might have led the investigators to suspect the existence of this newly discovered receptor? A. Activities of estrogen apparent less than 1 minute after application of the hormone B. The growth promoting activity of estrogen C. The presence of estrogen nuclear receptors in cells not previously known to respond to the hormone D. Estrogen is found in much higher concentrations in adult women than adult men E. Uptake of estrogen by target cells
Which of the following is true of signal transduction mediated by protein tyrosine kinases production of cAMP phosphoinositides are activated arrestins compete with G-proteins phosphorylation of tyrosine residues
In response to a hormone secreted by a cell of the opposite mating type, a yeast cell undergoes a complex series of physiological changes involving the activity of about 200 genes and cytoplasmic proteins. They include blockingDNA synthesis, growing toward the mating partner, fusion of the plasma membranes of the two cells, and fusion of their nuclear membranes. Explain how all these events can be controlled through a complex signaling cascade that is triggered by the binding of the hormone to a G protein–linkedreceptor.
In a hypothetical cAMP-mediated signal transduction cascade, the GTP-αs/adenylate cyclase interaction following a single hormone–receptor binding event lasts for 2.3 seconds. The catalytic rate (turnover number) for the adenylate cyclase in question is 350 cAMP molecules produced per second. How many cAMP molecules would be produced if five hormone-receptor binding events were to occur before the hormone molecule dissipates in the bloodstream? What is the amplification effect of this step in the signaling pathway?
Put the following steps for the outline of the growth factor signaling pathway in order: Map Kinase Kinase is Phosphorylated Proteins involved in gene transcription are activated Growth factor binds to its receptor in the cytoplasmic membrane Receptor recruits adaptor protein and GEF Autophosphorylation of tyrosine residues on the receptor Structural change of the receptor activates Tyrosine Kinase Map Kinase Kinase Kinase is phosphorylated Ras, a small GTPase, is activated by the exchange of GTP for GDP Map Kinase is Phosphorylated Map Kinase enters the nucleus
A small molecule binds to a G protein, preventing itsactivation. What direct effect will this have on signalingthat involves cAMP?a. The hormone will not be able to bind to thehormone receptor.b. Adenylyl cyclase will not be activated.c. Excessive quantities of cAMP will be produced.d. The phosphorylation cascade will be initiated.
In their mechanism of action, a difference between steroid and nonsteroid hormones is that __________. nonsteroid hormones bind to DNA steroid hormones enter the nucleus of the target cell, and nonsteroid hormones do not nonsteroid hormones cross the plasma membrane more readily than do steroid hormones steroid hormones use a signal transduction pathway