Which one of the following statements regarding Stage II of Catabolism is TRUE? O In Stage III, electrons carried by reduced cofactors NADH and FADH2 are ultimately transferred to O2. In Stage III, gluconeogenesis synthesizes glucose from lactate. Stage III involves the breakdown of lipids into fatty acids and glycerol. Stage III involves the conversion of acetyl CoA into pyruvate. Stage II only produces a total of 2 ATP per glucose.
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- Which of the following is most likely to cause accumulation of acetyl CoA? Group of answer choices There is not enough oxaloacetate present to run the citric acid cycle Increase activity of pyruvate dehydrogenase kinase Increased fatty acid synthesis Increased citrate synthase activity When fluoroacetate (an analog of acetate) is added to the mitochondria, it causes build up of fluorocitrate. Which of the following is most likely to be true? Group of answer choices Fluoroacetate cannot be converted to fluoroacetyl CoA Fluoroacetyl CoA cannot be combined with oxaloacetate to enter the citric acid cycle Addition of fluoroacetate will cause an increase in isocitrate Aconitase cannot use fluorocitrate as a substrateWhich of the following is a negative regulator of the pyruvate dehydrogenase complex (PDC)? 1. acetyl CoA 2. ADP 3. pyruvate 4. citrateWhich of the following statements are TRUE?Multiple answers are accepted for this question a .Two molecules of CO2 are produced each time a molecule of Acetyl-CoA is oxidized. b. During the first turn of the TCA Cycle the carbon atoms of Acetyl-CoA become CO2. c. The number of molecules of ATP that can be produced in the Citric Acid Cycle by substrate level phosphorylation of ADP from two molecules of Acetyl-CoA is 30. d. Fumarate contains a trans double bond. The cis isomer of Fumarate is Maleate which cannot serve as carbon source for a cell. e. Lack of O2 would decrease the rate of the Citric Acid Cycle in red blood cells. f. If a potent inhibitor of Succinyl-CoA Synthetaseis is applied to liver cells both energy production and synthesis of carbohydrate would be affected. g. The overall chemical changes that occur during one complete turn of the Citric Acid Cycle is the complete oxidation of one molecule of Acetyl-CoA plus the production of two molecules of CO2 plus the…
- Elevated levels of acetyl-CoA will act as an effector for which of the following enzymes? more than one can be correct Pyruvate carboxylase. Pyruvate kinase Pyruvate dehydrogenase. Citrate synthase a-Ketoglutarate dehydrogenase.What are the two most important carriers in one-carbonmetabolism? Give two examples of processes in which eachone participates.Which of the following conditions is most likely to force a muscle cell to metabolize glucose anaerobically(fermentation) under normal oxygenation ? - Glyceraldehyde-3-phosphate dehydrogenase deficiency - Lactate dehydrogenase deficiency -Pyruvate kinase deficiency -Aldolase deficiency - Cytososic Glycerol-3-phosphate dehydrogenase deficiency
- Which of the following is NOT a component of the pyruvate dehydrogenase complex? a. dihydrolipoyl dehydrogenase b. dihydrolipoyl transacetylase c. pyruvate dehydrogenase d. dihydrolipoyl catalaseIn the last step of glycolysis, phosphoenolpyruvate (PEP) is converted to pyruvate and during this reaction ATP is synthesized. Based on the fact that ATP is synthesized, which of the following enzymes would most likely catalyze this reaction? a. enolase b. pyruvate kinase c. aldolase d. pyruvate isomerase e. pyruvate dehydrogenaseA decrease in blood glucose levels will, in the liver, lead to the inhibition, either directly or indirectly, of which of the following enzymatic activities? Select one: a. Lactate dehydrogenase b. Phosphofructokinase c. Pyruvate kinase d. Enolase
- Assume that glycolysis is completely inhibited and thus glucose cannot be converted topyruvate. Which of the following statements is true?A. Levels of acetyl-CoA decrease in the liverB. Levels of oxaloacetate increase in the liverC. Both liver and brain primarily use b-hydroxybutyrate and acetoacetate as energy sourceD. None of the aboveWhy is it important that gluconeogenesis is not the exact reversal of glycolysis?The rate limiting and committed step of the pentose phosphate pathway is catalyzed by which of the following enzymes? A. Glucose-6-phosphate dehydrogenase B. Hexokinase C. 6-Phosphogluconate dehydrogenase D. Transketolase