Write the mechanism (in detail) for the conversion of aspartate and carbamoyl phosphate into N - carbamoylaspartate. Include a role for the histidine residue present in the active site.

Q: Please provide a chemical explanation for why the addition of water across the double bond is…

A: Metabolism is the chemical reactions that occur in cells and organisms. It involves catabolism and…

Q: Draw in detail the pathway of de novo synthesis of deoxythymidine phosphate and provide a brief…

A: First carbamoyl phosphate is synthesized , which then enters the de-novo synthesis pathway for…

Q: Illustrate the mechanism of action of ysozyme.

A: INTRODUCTION In many animal cells, lysosomes are found. Circular vesicles with hydrolytic enzymes…

Q: .Propose a mechanism for the conversion of 5- formamidoimidazole-4- carboxamide ribonucleotide into…

A: Purine is nucleic acids that are formed by the fusion of the pyrimidine ring with the imidazole ring…

Q: Explain how the conversion of alanine to pyruvic acid (pyruvate) can be identified as an oxidation…

A: Oxidation is the gain of oxygen, loss of electrons, and loss of hydrogen from an atom. The oxidation…

Q: Complex allosteric regulation of the aspartate transcarbamoylase reaction is significant because it…

A: Aspartate transcarbomylase (ATCase) catalyzes the first step in pyrimidine biosynthesis. Aspartate…

Q: Explain why methotrexate inhibits the synthesis of histidine and methionine.

A: Competitive inhibition is the competition between a substrate and inhibitor that compete for the…

Q: Describe the application of transamination in the biosynthesis of shikimate derivatives. Show how…

A: Shikimic is derived from the Japanese flower shikimi (Japanese star anise, Illicium anisatum), from…

Q: cyclophosmamide

A:

Q: Considering the general structure of penicillins, how are they rendered ineffective?   Select…

A: Penicillin is an antibiotic that inhibits the formation of peptidoglycan cross-links of the…

Q: An inhibitor that specifically labels chymotrypsin at histidine 57 is N-tosylamido-l-phenylethyl…

A: Trypsin is an enzyme that helps to digest protein. It breaks down the process of digestion that…

Q: What is the evidence that aspartate transcarbamoylase (ATCase) effects catalysis primarily by…

A: Aspartate carbamyl transferase or astartate transcarbamoylase, transfers a carbamoyl group from…

Q: Write out a mechanism for the serine triad hydrolysis ofglycylglycine.

A: The dipeptide unit of glycine is glycylglycine. Serine proteases are a group of enzymes that contain…

Q: Propose a mechanism for the conversion of glucose 6-phosphate into fructose 6- phosphate by…

A: Glycolysis is the oxidation process of glucose to yield high-energy compounds such as ATP . The…

Q: Consider the dextran sucrase reaction. Why do you suppose there is not an ATP requirement to…

A: Dextran sucrase is an enzyme that catalyses the chemical reaction.

Q: Transamination reactions have been described as ping-pong reactions. Use the reaction of alanine…

A: Ping pong mechanism is a double displacement reaction where Enzyme binds with the substrate to form…

Q: Briefly describe the role of nucleophilic catalysis in the mechanism of the chymotrypsin reaction.

A: Chymotrypsin is the enzyme synthesized in the pancreas in the form of the inactive state known as…

Q: Why is the formation of fructose1,6bisphosphate a step in which control is likely to be exercised in…

A: The cellular processes occur via stepwise chemical reactions in which these reactions are…

Q: Pyridoxal phosphate acts as an intermediate carrier of amino groups during transamination reactions.…

A: Pyridoxal phosphate is the active form of Vit B6. It is a coenzyme in a variety of enzymatic…

Q: A pentapeptide was found to have the composition Ala Arg Gly Pro Trp. Reaction of the pentapeptide…

A: Pentapeptide is made of five amino acids that are connected by the four peptide bonds. The end with…

Q: for GABA transaminase, ornithine decarboxylase, and alanine

A: PLP-dependent enzymes catalyse a wide range of reactions that result in bond cleavage at the carbons…

Q: Describe a common feature at the active site of serine proteases and acetyl cholinesterase

A: Acetylcholinesterase is an enzyme that catalyzes the hydrolysis of acetylcholine (which is a…

Q: Match each of the enzymes involved in de novo pyrimidine synthesis with the correct description:…

A:

Q: If you were to determine the P/O ratio for oxidation of a-ketoglu- tarate, you would probably…

A: During the oxidation of α-ketoglutarate, some malonate may be added to block succinate…

Q: Consider the complete oxidation of a mixed TAG containing the following fatty acid residues: At…

A: Background information for Triglycerides or Triacylglycerols (TAG) Triacylglycerols are a group of…

Q: Draw the mechanism for the hydrolysis of the peptide bonds of aspartame. Draw all arrows

A: Aspartame is a polypeptide made up of amino acids, It is a kind of sugar substitute utilized as a…

Q: The cleavage of fructose-1,6-bisphosphate to glyceraldehyde3-phosphate and dihydroxyacetone…

A: Glycolysis is the metabolic oxidation process that occurs in the cytosol of every cell. where it…

Q: The glycerol 3-phosphate required for the synthesis of glycerophospholipids can be synthesized from…

A: Glucose is the primary energy source in almost all living organisms. Glucose is broken down to form…

Q: What is the rationale in using hexokinase and G6PD in the in the reverse reaction of Oliver-Rosalki?

A: Oliver rosalki method: The method of analysis of creatine kinase by measuring the Absorbance of NADH…

Q: Briefly discuss the synthesis of selenocysteine amino acid.

A: Selenocysteine(Sec): It is the 21 st amino acid of the genetic code and this amino acid contains…

Q: When alanine undergoes transamination with oxaloacetate, alanine is first converted to alpha-keto…

A: Transamination is defined as the exchange of functional groups that happens between most amino acids…

Q: What cofactors are necessary for methyltransferases t Homocysteine Methionine o work?

A: Methyltransferases are primarily responsible for the transfer of methyl groups to other molecules.

Q: Propose a mechanism for the biosynthesis of a-terpineol from geranyl pyrophosphate

A: Alpha-terpineol is an alcohol. It is prevalent in natural oils like pine oil. Terpineol has four…

Q: . Propose a chemical mechanism for the reaction catalyzed by the PLP-dependent glatamate…

A: Glutamate-1-semialdehyde 2,1-aminomutase is an enzyme which belongs to the family isomerases;…

Q: Reaction mechanism for the transamination of alanine based on this figure

A: Transamination is defined as the exchange of functional groups that happens between most amino acids…

Q: .N. NH2 R COOH соон `NH2 Pyridoxamine Pyruvic acid Alanine A

A: It is a transamination reaction in which an amino acid is synthesized.

Q: Normal cells die in a nutrient medium containing thymidine and methotrexate, whereas mutant cells…

A: Methotrexate is a chemotherapy agent which is used to treat cancer, autoimmune diseases, ectopic…

Q: Identify each of the following biomolecules. Explain the function of each in biochemical processes.…

A: Biomolecules are macromolecules that are composed of carbon, hydrogen, oxygen, and nitrogen…

Q: Xanthine oxidase treated with allopurinol results in the formation of a new compound that is an…

A: Xanthine oxidase belongs to the class of oxidoreductase. This enzyme produces reactive oxygen atoms…

Q: Serine esterase contains a catalytic triad at its active site. Which amino acid in serine esterase…

A: Serine esterase contains three amino acids, His 57,Ser 195 and Asp 102.These three residues form a…

Q: The key regulatory enzyme in pyrimidine synthesis is: a. Aspartate transcarbamoylase. b. Glutamine…

A: Pyrimidine synthesis takes place in cytoplasm. Pyrimidine is synthesized as a free ring and then a…

Q: Give the simplified representation of the pentose phosphate pathway.

A: Pentose phosphate pathway (PPP) is also known as phosphogluconate pathway and also called as hexose…

Q: Show the steps using in the Biosynthesis of isopentenyl pyrophosphate.

A: The Mevalonate pathway is the metabolic pathway that involves the biosynthesis of cholesterol…

Q: In the pyrimidine degradative pathway, all pyrimidines undergo conversion to uracil, which undergoes…

A: Pyrimidines are one of the two classes of heterocyclic nitrogenous bases found in the nucleic acids…

Q: Explain the basis for the following statement. For efficient conver- sion of galactose to…

A: UDP : Uridine diphosphate glucose is a nucleotide sugar. It is involved in glycosyltransferase…

Q: The purinosome contains enzymes that convert the serine hydroxymethyl group to the formyl group of…

A: Purinosome refers to a multi-enzyme complex, which is involved in carrying out the purine…

Q: Briefly describe the induced-fit conformational change when hexokinase binds its substrate.

A: Hexokinase is considered as the catalytic enzyme, which is involved in the glycolysis process.

Q: Some microorganisms lack DHFR activity, but their thymidylate synthase has an FAD cofactor. What is…

A: An organism evolves to find an alternative mechanism to continue the biochemical process. FAD is a…

Metabolic pathways

Metabolism is defined as the group of life-supporting, enzyme-mediated chemical reactions in organisms. A metabolic pathway is a set of these chemical reactions that involve anabolism (synthesis of complex biomolecules) and catabolism (breakdown of biomolecules into small molecules) that occur inside a cell. Metabolites are the reacting substances, products, and intermediate substances of an enzymatic process that are altered by a series of chemical events catalyzed by enzymes.