The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK a values. pK a values are given as: phosphoric acid- 1×10 -3 , hydrogen sulfide- 1×10 -7 , alcohols- 1×10 -17 and ammonia- 1×10 -36 . Introduction: pK a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK a , the smaller is the extent of dissociation.

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Answer 1

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Chapter 1, Problem 66TQ

Summary Introduction

To review:

The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK_a values. pK_a values are given as: phosphoric acid- 1×10^-3, hydrogen sulfide- 1×10^-7, alcohols- 1×10^-17 and ammonia- 1×10^-36 .

Introduction:

pK_a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK_a, the smaller is the extent of dissociation.

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Answer 2

Question

Chapter 1, Problem 66TQ

Summary Introduction

To review:

The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK_a values. pK_a values are given as: phosphoric acid- 1×10^-3, hydrogen sulfide- 1×10^-7, alcohols- 1×10^-17 and ammonia- 1×10^-36 .

Introduction:

pK_a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK_a, the smaller is the extent of dissociation.

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Answer 3

Question

Chapter 1, Problem 66TQ

Summary Introduction

To review:

The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK_a values. pK_a values are given as: phosphoric acid- 1×10^-3, hydrogen sulfide- 1×10^-7, alcohols- 1×10^-17 and ammonia- 1×10^-36 .

Introduction:

pK_a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK_a, the smaller is the extent of dissociation.

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Answer 4

Question

Chapter 1, Problem 66TQ

Summary Introduction

To review:

The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK_a values. pK_a values are given as: phosphoric acid- 1×10^-3, hydrogen sulfide- 1×10^-7, alcohols- 1×10^-17 and ammonia- 1×10^-36 .

Introduction:

pK_a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK_a, the smaller is the extent of dissociation.

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Answer 5

Chapter 1, Problem 66TQ

Summary Introduction

To review:

The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK_a values. pK_a values are given as: phosphoric acid- 1×10^-3, hydrogen sulfide- 1×10^-7, alcohols- 1×10^-17 and ammonia- 1×10^-36 .

Introduction:

pK_a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK_a, the smaller is the extent of dissociation.

Answer 6

Chapter 1, Problem 66TQ

Summary Introduction

To review:

The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK_a values. pK_a values are given as: phosphoric acid- 1×10^-3, hydrogen sulfide- 1×10^-7, alcohols- 1×10^-17 and ammonia- 1×10^-36 .

Introduction:

pK_a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK_a, the smaller is the extent of dissociation.

Answer 7

Chapter 1, Problem 66TQ

Summary Introduction

To review:

The order of reactivity in nucleophilic substitution reactions: phosphate>thiols>esters>amides, based on the pK_a values. pK_a values are given as: phosphoric acid- 1×10^-3, hydrogen sulfide- 1×10^-7, alcohols- 1×10^-17 and ammonia- 1×10^-36 .

Introduction:

pK_a is an acid dissociation constant; it gives a quantitative measure of an acid’s strength in a solution. It shows the tendency of an acid to be able to lose a proton. The more positive the value of pK_a, the smaller is the extent of dissociation.

Answer 8

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Answer 11

Ch. 1 - Prob. 1RQ Ch. 1 - Prob. 2RQ Ch. 1 - Prob. 3RQ Ch. 1 - Prob. 4RQ Ch. 1 - Prob. 5RQ Ch. 1 - Prob. 6RQ Ch. 1 - Prob. 7RQ Ch. 1 - Prob. 8RQ Ch. 1 - Prob. 9RQ Ch. 1 - Prob. 10RQ

Solution Summary: The author analyzes the order of reactivity in nucleophilic substitution reactions based on the pK a values.

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