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It is commonplace to gain weight after quitting smoking. To determine the effectiveness of the drug Naltrexone in limiting weight gain after quitting smoking, 147 subjects who smoked 20 or more cigarettes daily were randomly divided into two groups. All 147 subjects received a 21-milligram (mg) transdermal nicotine patch (to curb nicotine cravings while trying to quit smoking). However, seventy-two subjects received a placebo, while 75 received 25 mg of Naltrexone. After 6 weeks, the placebo subjects had a
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