IA MODIFIED MASTERING BIOLOGY WITH E TEX
12th Edition
ISBN: 9780136781752
Author: Urry
Publisher: PEARSON
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Textbook Question
Chapter 11, Problem 2TYU
The activation of receptor tyrosinc kinases is characterized by
(A) dimeiization and phosphorylation.
(B) dimerization and IP3 binding.
(C) a phosphorylation cascade.
(D) GTP liydrolysis.
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3) Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly.
The activated receptor stimulates a G protein, which opens a K+ channel in the
plasma membrane, as shown in Figure 1. Which of the following would enhance
this effect of the acetylcholine?
(a)
(b)
(c)
(d)
Figure 1
addition of a high concentration of a non-hydrolyzable analog of GTP
addition of a drug that prevents the a subunit from exchanging GDP for
GTP
mutations in the acetylcholine receptor that weaken the interaction
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mutations in the acetylcholine receptor that weaken the interaction
between the receptor and the G protein
Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium. They have an important role in vascular homeostasis. Endothelin activates G protein-coupled receptors (GPCRs) ETA or ETB on a target cell. Which subunit of heterotrimeric G protein is released when the receptor is activated?
a.) gamme
b.) beta
c.) alpha
Signaling molecules interact with cells through specific macromolecular
receptors. For each of the four receptors identified below, list all characteris-
tics, by number, which accurately describe that receptor.
(a) An adrenergic receptor
(b) A steroid receptor
(c) The LDL receptor.
(d) The insulin receptor,
(1) Located at the cell surface
(2) Associated with the protein clathrin
(3) Ligand binding stimulates the activity of phospholipase C
(4) A transmembrane protein
(5) A DNA-binding protein
(6) Located in the cell interior
(7) Receptor-ligand complex moves to the lysosome
(8) Receptor-ligand complex becomes concentrated in the nucleus
(9) Receptor activation can inhibit the synthesis of glycogen
(10) The hormone-receptor complex activates specific gene transcription
(11) Internalization decreases the synthesis of cholesterol esters
Chapter 11 Solutions
IA MODIFIED MASTERING BIOLOGY WITH E TEX
Ch. 11.1 - Explain how signaling is involved in ensuring that...Ch. 11.1 - In liver cells, glycogen Phosphorylase acts in...Ch. 11.1 - Prob. 3CCCh. 11.2 - Prob. 1CCCh. 11.2 - WHAT IF? What would the effect be if a cell made...Ch. 11.2 - MAKE CONNECTIONS How is ligand binding similar to...Ch. 11.3 - What is a protein kinase, and what is its role in...Ch. 11.3 - When a signal transduction pathway involves a...Ch. 11.3 - What is the actual signal that is being transduced...Ch. 11.3 - WHAT IF? If you exposed a cell to a ligand that...
Ch. 11.4 - How can a targct cell's response to a single...Ch. 11.4 - WHAT IF? If two cells have different scaffolding...Ch. 11.4 - Prob. 3CCCh. 11.4 - Prob. 4CCCh. 11.5 - Give an example of apoptosis during embryonic...Ch. 11.5 - WH AT IF? If apoptosis occurred when it should...Ch. 11 - What determines whether a cell responds to a...Ch. 11 - How are the structures of a GPCR and an RTK...Ch. 11 - What is the difference between a protein kinase...Ch. 11 - What mechanisms in the cell terminale its response...Ch. 11 - What is an explanation for the similarities...Ch. 11 - Binding of a signaling molecule to which type of...Ch. 11 - The activation of receptor tyrosinc kinases is...Ch. 11 - Lipid-soluble signaling molecules, such as...Ch. 11 - Consider this pathway: epinephrine G...Ch. 11 - Apoptosis involves all but which of the following?...Ch. 11 - Which Observation suggestcd to Sutherland the...Ch. 11 - Prob. 7TYUCh. 11 - DRAW IT Draw the following apoptotic pathway,...Ch. 11 - EVOLUTION CONNECTION Identify the evolutlonary...Ch. 11 - Prob. 10TYUCh. 11 - SCIENCE, TECHNOLOGY, AND SOCIETY The aging process...Ch. 11 - WRITE ABOUT A THEME: ORGANIZATION The properties...Ch. 11 - SYNTHESIZE YOUR KNOWLEDGE There are five basic...
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