A geneticist student noticed a newborn baby having some physical abnormalities, in a painting during her visit to a museum and wondering whether this condition is a genetic disorder. After searching online, she learned that baby might be having RBS (Roberts syndrome) in which mitotic errors occur. These errors include the premature separation of the centromeres and other heterochromatic regions of homologs in metaphase instead of anaphase. RBS is caused by the ESCO2 gene’s mutant alleles that functions during cell division. Characters in the case: A geneticist student, a painting showing a woman (mother) and a newborn baby. Adequate information: A newborn baby is having short arms and legs with some facial abnormalities. To determine: The reason for premature separation of centromeres causes the problems seen in RBS. Given the information: The abnormalities in the newborn baby are reported as Roberts syndrome (RBS) by online searching.

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Chapter 11, Problem 3CS

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Case Summary:

A geneticist student noticed a newborn baby having some physical abnormalities, in a painting during her visit to a museum and wondering whether this condition is a genetic disorder. After searching online, she learned that baby might be having RBS (Roberts syndrome) in which mitotic errors occur. These errors include the premature separation of the centromeres and other heterochromatic regions of homologs in metaphase instead of anaphase. RBS is caused by the ESCO2 gene’s mutant alleles that functions during cell division.

Characters in the case:

A geneticist student, a painting showing a woman (mother) and a newborn baby.

Adequate information:

A newborn baby is having short arms and legs with some facial abnormalities.

To determine:

The reason for premature separation of centromeres causes the problems seen in RBS.

Given the information:

The abnormalities in the newborn baby are reported as Roberts syndrome (RBS) by online searching.

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