Human Physiology: An Integrated Approach (8th Edition)
Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 11.1, Problem 9CC
Summary Introduction

To determine: Whether chromaffin cells contain muscarinic or nicotinic acetylcholine (Ach) receptors.

Introduction: The autonomic neurons have targets for cardiac muscle, few exocrine glands, smooth muscle, and some endocrine glands and also for lymphoid tissue and liver. Neuroeffector junction is defined usually as a synapse between a postganglionic autonomic neuron and its target cell.

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Which statement about nicotinic acetylcholine receptors (nAChRs) is true? a. Each nAChR is composed of seven different protein subunits.   b. They are ionotropic receptors and conduct Na+ and Ca2+ ions across the cell membrane causing depolarization and a fast excitatory response.   c. They are ionotropic receptors and conduct K+ ions across the cell membrane, causing depolarization and a fast excitatory response.   d. They are found in all areas of the nervous system except the brain.
Give an account of signalling at a neuromuscular junction through the nicotinic acetylcholine receptor.
Explain how ligand-gated channels are opened, using nicotinic ACh receptors as an example.
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