Concept explainers
Sharpless
Want to see the full answer?
Check out a sample textbook solutionChapter 12 Solutions
Package: Loose Leaf Organic Chemistry with Connect 2-year Access Card
Additional Science Textbook Solutions
Principles of Chemistry: A Molecular Approach (3rd Edition)
Organic Chemistry
Chemistry: An Introduction to General, Organic, and Biological Chemistry (12th Edition) - Standalone book
Chemistry: Structure and Properties
- Dihydropyran is synthesized by treating tetrahydrofurfuryl alcohol with an arenesulfonic acid, ArSO3H. Propose a mechanism for this conversion.arrow_forwardCembrene, C20H32, is a diterpenoid hydrocarbon isolated from pine resin. Cembrene has a UV absorption at 245 nm, but dihydrocembrene (C20H34), the product of hydrogenation with 1 equivalent of H2, has no UV absorption. On exhaustive hydrogenation, 4 equivalents of H2 react, and octahydrocembrene, C20H40, is produced. On ozonolysis of cembrene, followed by treatment of the ozonide with zinc, four carbonylcontaining products are obtained: Propose a structure for cembrene that is consistent with its formation from geranylgeranyl diphosphate.arrow_forwardIdentify compounds A, B, and C. a. Compound A has molecular formula C8H12 and reacts with two equivalents of H2. A gives HCOCH2CH2CHO as the only product of oxidative cleavage with O3 followed by CH3SCH3. b. Compound B has molecular formula C6H10 and gives (CH3)2CHCH2CH2CHCH3 when treated with excess H2 in the presence of Pd. B reacts with NaNH2 and CH3I to form compound C (molecular formula C7H12).arrow_forward
- Identify compounds A, B, and C. a.Compound A has molecular formula C8H12 and reacts with two equivalents of H2. A gives HCOCH2CH2CHO as the only product of oxidative cleavage with O3 followed by CH3SCH3. b.Compound B has molecular formula C6H10 and gives (CH3)2CHCH2CH2CH3 when treated with excess H2 in the presence of Pd. B reacts with NaNH2 and CH3I to form compound C (molecular formula C7H12).arrow_forwardHeating compound X with aqueous formaldehyde forms Y (C17H23NO), which has been converted to a mixture of lupinine and epilupinine, alkaloids isolated from lupin, a perennial ornamental plant commonly seen on the roadside in parts of Alaska. Identify Y and explain how it is formed.arrow_forwardWhen attached halohydrin is treated with NaH, a product of molecularformula C4H8O is formed. Draw the structure of the product and indicateits stereochemistry.arrow_forward
- When attached halohydrin is treated with NaH, a product of molecular formula C4H8O is formed. Draw the structure of the product and indicateits stereochemistry.arrow_forwardAlthough alcohol V gives a single alkene W when treated with POCl3 and pyridine, three isomeric alkenes (X–Z) are formed on dehydration with H2SO4. Draw a stepwise mechanism for each reaction and explain why the difference occurs.arrow_forwardDraw a stepwise mechanism for the reduction of epoxide A to alcohol B using LiAlH4. What product would be formed if LiAlD4 were used as reagent? Indicate the stereochemistry of all stereogenic centers in the product using wedges and dashed wedges.arrow_forward
- β-ocimene is a pleasant smelling hydrocarbon found in the leaves of a certain herbs. It has a molecular formula C10H16 and a UV absorption λmax 232nm. On hydrogenation with a palladium catalyst, 2,6-dimethyloctane is obtained. Ozonolysis β-ocimene followed by the treatment with zinc and acetic acid produces the following fragments:arrow_forward(a) Explain how NaBH4 in CH3OH can reduce hemiacetal A to butane-1,4-diol (HOCH2CH2CH2CH2OH). (b) What product is formed when A is treated with Ph3P = CHCH2CH(CH3)2? (c) The drug isotretinoin is formed by reaction of X and Y. What is the structure of isotretinoin? Although isotretinoin (trade name Accutane or Roaccutane) is used for the treatment of severe acne, it is dispensed under strict controls because it also causes birth defects.arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning