(a) Interpretation: The hypothesis for the different results of ibuprofen and indomethacin inhibitors should be determined. Concept introduction: The substances that are added in a reaction in order to slow down it or to prevent the formation of unwanted products are called inhibitors. These are just the opposite of catalysts. There are three types of inhibitors: Competitive inhibitors: These occupy the region where the substrate is to be placed and therefore it blocks the active site of the enzyme. Methotrexate is an example of a competitive inhibitor. Uncompetitive inhibitors: These bind to enzyme-substrate complex and therefore the enzyme becomes unable to react with the substrate. Lansoprazole is an example of an uncompetitive inhibitor. Non-competitive inhibitors: These bind to some region of the enzyme other than the active site and alter its shape. Phenethyl isothiocyanate is an example of a non-competitive inhibitor.

Question

MULTIPLE CHOICE In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not A. decrease de novo pyrimidine synthesis B. decrease de novo purine synthesis C. decrease urate synthesis D. increase PRPP levels (Phosphoribosyl pyrophosphate)

Answer 1

Question

Chapter 12, Problem 18P

Interpretation Introduction

(a)

Interpretation:

The hypothesis for the different results of ibuprofen and indomethacin inhibitors should be determined.

Concept introduction:

The substances that are added in a reaction in order to slow down it or to prevent the formation of unwanted products are called inhibitors. These are just the opposite of catalysts. There are three types of inhibitors:

Competitive inhibitors: These occupy the region where the substrate is to be placed and therefore it blocks the active site of the enzyme. Methotrexate is an example of a competitive inhibitor.

Uncompetitive inhibitors: These bind to enzyme-substrate complex and therefore the enzyme becomes unable to react with the substrate. Lansoprazole is an example of an uncompetitive inhibitor.

Non-competitive inhibitors: These bind to some region of the enzyme other than the active site and alter its shape. Phenethyl isothiocyanate is an example of a non-competitive inhibitor.

Interpretation Introduction

(b)

Interpretation:

The results with the use of aspirin should be determined.

Concept introduction:

The substances that are added in a reaction in order to slow it down or to prevent the formation of unwanted products are called inhibitors. These are just the opposite of catalysts. There are three types of inhibitors:

Competitive inhibitors: These occupy the region where the substrate is to be placed and therefore it blocks the active site of the enzyme. Methotrexate is an example of a competitive inhibitor.

Uncompetitive inhibitors: These bind to enzyme-substrate complex and therefore the enzyme becomes unable to react with the substrate. Lansoprazole is an example of an uncompetitive inhibitor.

Non-competitive inhibitors: These bind to some region of the enzyme other than the active site and alter its shape. Phenethyl isothiocyanate is an example of a noncompetitive inhibitor.

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