Chapter 12.3, Problem 120E

Neutropenia. Neutropenia is an abnormally low number of neutrophils (a type of white blood cell) in the blood. Chemotherapy often reduces the number of neutrophils to a level that makes patients susceptible to fever and infections. G. Bucaneve et al. published a study of such cancer patients in the paper “Levofloxacin to Prevent Bacterial Infection in Patients With Cancer and Neutropenia” (New England Journal of Medicine, Vol. 353, No. 10, pp. 977-987). For the study, 375 patients were randomly assigned to receive a daily dose of levofloxacin, and 363 were given placebo. In the group receiving levofloxacin, fever was present in 243 patients for the duration of neutropenia, whereas fever was experienced by 308 patients in the placebo group.

1. a. At the 1% significance level, do the data provide sufficient evidence to conclude that levofloxacin is effective in reducing the occurrence of fever in such patients?
2. b. Find a 98% confidence level for the difference in the proportions of such cancer patients who would experience fever for the duration of neutropenia.