The evidence shown in the graphs support the hypothesis that weakened binding between sister chromatids leads to aneuploidy. Introduction: Aneuploidy refers to the presence of an abnormal number of chromosomes in the cell. It has been hypothesized that the older women produce more aneuploid eggs because the binding between sister chromatids becomes weaker in oocytes of older women. Researchers used female mice of different ages as a model for aging in women. They measured the percentage of aneuploid eggs, analyzed chromosomes in meiosis for the amount of cohesin connecting the sister chromatids, and measured the distance between sister kinetochores. The given graphs are shown below:

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Chapter 13, Problem 11PIAT

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The evidence shown in the graphs support the hypothesis that weakened binding between sister chromatids leads to aneuploidy.

Introduction:

Aneuploidy refers to the presence of an abnormal number of chromosomes in the cell. It has been hypothesized that the older women produce more aneuploid eggs because the binding between sister chromatids becomes weaker in oocytes of older women.

Researchers used female mice of different ages as a model for aging in women. They measured the percentage of aneuploid eggs, analyzed chromosomes in meiosis for the amount of cohesin connecting the sister chromatids, and measured the distance between sister kinetochores. The given graphs are shown below:

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Construct a table similar to that in Figure 2.12 for the different stages of meiosis, giving the number of chromosomes per cell and the number of DNA molecules per cell for a cell that begins with 4 chromosomes (two homologous pairs) in G1. Include the following stages in your table: G1, S, G2, prophase I, metaphase I, anaphase I, telophase I (after cytokinesis), prophase II, metaphase II, anaphase II, and telophase II (after cytokinesis).

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