Campbell Biology: Concepts & Connections, Books a la Carte Plus Mastering Biology with Pearson eText - Access Card Package (9th Edition)
9th Edition
ISBN: 9780134536347
Author: Martha R. Taylor, Eric J. Simon, Jean L. Dickey, Kelly A. Hogan, Jane B. Reece
Publisher: PEARSON
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Chapter 13, Problem 12TYK
Sickle-cell disease is caused by a recessive allele. Roughly one out of every 400 African Americans (0.25%) is afflicted with sickle-cell disease. Use the Hardy-Weinberg equation to calculate the percentage of African Americans who are carriers of the sickle-cell allele. (Hint: q2 = 0.0025 .)
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If the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by a rare clinically relevant allele is 1/8500 in a given population, what is the carrier frequency? Please give your answer as a percentage to 3 decimal places, do not include the % symbol.
ANSWER: In a population where the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known mutation is 1/8500 the carrier frequency is a percent.
In the genetics unit you learned that sickle cell anemia is an autosomal recessive condition. In 2016, assume in the City of Markham there are 1000 people out of 300000 people who have sickle cell anemia. Assume global warming continues for the next 50 years and in the year 2066 there are 20000 people out of 500000 in Markham who have sickle cell anemia. a)What are the allele frequencies in 2016? What are the allele frequencies in 2066? Is microevolution evident? b)Due to global warming, assume the numbers of malaria carrying mosquitoes in Markham dramatically increased between 2016 and 2066. What do you believe is the main cause of the microevolution in Markham? (Hint- refer to the 5 factors affecting microevolution and refer back…
A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population?
A1A1 = 30 A1A2 = 27 A2A2 = 12
A1A3 = 17 A2A3 = 10 A3A3 = 4
What is the frequency of A1 allele in the population?
A.
0.375
B.
0.52
C.
0.305
D.
0.175
E.
0.74
Chapter 13 Solutions
Campbell Biology: Concepts & Connections, Books a la Carte Plus Mastering Biology with Pearson eText - Access Card Package (9th Edition)
Ch. 13 - Summarize the key points of Darwins theory of...Ch. 13 - Complete this concept map describing potential...Ch. 13 - Which of the following did not influence Darwin as...Ch. 13 - Natural selection is sometimes described as...Ch. 13 - In an area of erratic rainfall, a biologist found...Ch. 13 - If an allele is recessive and lethal in...Ch. 13 - In a population with two alleles, B and b, the...Ch. 13 - Within a few weeks of treatment with the drug 3TC,...Ch. 13 - In the late 1700s, machines that could blast...Ch. 13 - Write a paragraph briefly describing the kinds of...
Ch. 13 - In the early 1800s, French naturalist Jean...Ch. 13 - Sickle-cell disease is caused by a recessive...Ch. 13 - It seems logical that natural selection would work...Ch. 13 - SCIENTIFIC THINKING Cetaceans are fully aquatic...Ch. 13 - A population of snails is preyed on by birds that...Ch. 13 - Advocates of scientific creationism and...
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- What is a Mendelian population? How is the gene pool of a Mendelian population usually described?arrow_forwardIf a mother with sickle-cell anemia and a father with the sickle-cell trait havechildren, calculate the percentages of each genotype and phenotype of the offspring from the Punnett square.arrow_forwardIf the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known clinically relevant allele is 1/8500 in a given population, what is the frequency of the wild type allele? Please give your answer as a percentage to 3 decimal places, do not include the % symbol.arrow_forward
- Using the observed counts for each genotype, how do you find the expected values with those numbers and the frequencies?arrow_forwardIf a trait determined by autosomal recessive allele occurs at a frequency of 0.25 in a population, what are the allelic frequencies? Assume Hardy-Weinberg equilibrium and use A and a to symbolize the dominant and recessive alleles, respectively. Show calculation.arrow_forwardIf the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by a rare clinically relevant allele is 1/9250 in a given population, what is the carrier frequency? Please give your answer as a percentage to 3 decimal places, do not include the % symbol.arrow_forward
- . If the frequency of the homozygous recessive genotype is 0.81, what is the frequency of the recessive allele?arrow_forwardA given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population? A1A1 = 30 A1A2 = 27 A2A2 = 12 A1A3 = 17 A2A3 = 10 A3A3 = 4 What would be the frequency of the A3A3 genotype? Assume the population is under Hardy-Weinberg equilibrium. A. 0.182 B. 0.27 C. 0.03 D. 0.317 E. 0.107 F. 0.09arrow_forwardPlease read the scenario below, and then answer the question (in bold) that follows. Tay-Sachs disease is a fatal autosomal recessive disorder in children (usually by age 5) that causes a progressive degeneration of the central nervous system. This disease affects 1 in 3,500 newborns of European Ashkenazi Jewish ancestry in the U.S. population. What is the number of carriers in the population? a. 1 person b. 60 persons c. 116 persons d. 3,383 persons e. 3,441 personsarrow_forward
- Using the HardyWeinberg Law in Human Genetics Suppose you are monitoring the allelic and genotypic frequencies of the MN blood group locus (see Question 2 for a description of the MN blood group) in a small human population. You find that for 1-year-old children, the genotypic frequencies are MM = 0.25, MN = 0.5, and NN = 0.25, whereas the genotypic frequencies for adults are MM = 0.3, MN = 0.4, and NN = 0.3. a. Compute the M and N allele frequencies for 1-year-olds and adults. b. Are the allele frequencies in equilibrium in this population? c. Are the genotypic frequencies in equilibrium?arrow_forwardCystic fibrosis is a genetic disease mostly affecting people of European descent that is caused by a recessive allele. You sample 1000 people for this allele and find 772 homozygous normal individuals, 221 heterozygotes, and 7 people homozygous for cystic fibrosis. Is this population in Hardy-Weinberg equilibrium?arrow_forwardAt the beginning of the film, you were introduced to Davaun and Skyy Cooper, who both have sickle cell disease. Which of the following must be true about their parents? Group of answer choices One parent has at least one copy of the sickle cell allele. Both parents have at least one copy of the sickle cell allele. Both parents have sickle cell disease. One parent has sickle cell disease.arrow_forward
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