Concept explainers
(a)
To explain: The effect on normal kinetics of microtubule assembly, after adding a small amount of Nocodazole in the preparation.
Introduction: The concentration of tubulin dimmers is responsible for microtubule growth. Addition of any drug to the cell may affect its assembly and disassembly to the microtubules. Every drug has its mechanism that depolymerizes the microtubule of an animal cell.
(b)
To explain: The reason why the microtubules of an animal cell depolymerize and virtually disappear when it is treated with colchicine, and when the colchicine is washed away, the microtubules appear again, beginning at the centrosome and elongating outward.
Introduction: The concentration of tubulin dimmers is responsible for microtubule growth. Addition of any drug to the cell may affect its assembly and disassembly to the microtubules. Every drug has its own mechanism that depolymerizes an animal cell.
(c)
To explain: The reason why the induced microtubules contain a subunit of γ tubulin is observed by immunostaining; even it is made up of other subunits.
Introduction: The concentration of tubulin dimmers is responsible for microtubule growth. The concentration of tubulin heterodimer, at which the assembly and disassembly of the microtubule maintain, is called as critical concentration.
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