Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 13, Problem 4TY
Summary Introduction
Introduction: Humans and other mammals have an ncRNA known as the HOTAIR that repress gene transcription. HOTAIR is encoded by a gene present in the cluster of HoxC genes. The transcription of the HOTAIR strand is from a stand that is antisense to a HoxC gene.
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Compare and contrast the role of promoter and operators with enhancers and repressors.
Suggest a direct experiment to prove that p53 binding at gene promoters affects the level of gene expression of the corresponding genes.
What is the role of a substrate that controls a repressible operon?
a.
increase the production of inactive repressor proteins
b.
bind to the repressor protein and activate it
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bind to the repressor protein and deactivate it
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bind to the promoter region and decrease the affinity of RNA polymerase for the promoter
Chapter 13 Solutions
Biology
Ch. 13.1 - Prob. 1CCCh. 13.2 - Prob. 1CCCh. 13.3 - Prob. 1EQCh. 13.3 - Prob. 2EQCh. 13.3 - Prob. 3EQCh. 13.3 - Effects of Non-coding RNAs on Translation and mRNA...Ch. 13.4 - Non-coding RNAs and Protein Sorting Core Skill:...Ch. 13.5 - Core Skill: Modeling The goal of this modeling...Ch. 13 - Prob. 1TYCh. 13 - Prob. 2TY
Ch. 13 - Prob. 3TYCh. 13 - Prob. 4TYCh. 13 - Prob. 5TYCh. 13 - Prob. 6TYCh. 13 - With regard to miRNAs and siRNAs, which of the...Ch. 13 - Cas1 and Cas2 proteins play a role during which of...Ch. 13 - Which of the following components bind to...Ch. 13 - Abnormalities in the expression of ncRNAs are...Ch. 13 - An ncRNA may have one or more of the following...Ch. 13 - What is RNA interference (RNAi)? Explain how the...Ch. 13 - Prob. 3CQCh. 13 - Prob. 1COQCh. 13 - Go to the PubMed website and search for non-coding...
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- Through alternative splicing, eukaryotes (a) reinforce gene inactivation (b) prevent transcription of heterochromatin (c) produce related but different proteins in different tissues (d) amplify genes to meet the requirement of high levels of a gene product (e) bind transcription factors to enhancers to activate transcriptionarrow_forwardCompare and contrast the activities of an activator protein anda repressor protein.arrow_forwardThe “domain-swapping” experiment that grafts the Gal4 DNA-binding domain to the LexA activation domain generates a chimeric protein that will: A) bind to the Gal4 site. B) bindto the LexA site. C) activate transcription of the LexA gene. D) activate transcription of alleukaryotic genes. E) All of the answer options are correct.arrow_forward
- Binding of _______ to _______ in DNA can increase the rate of transcription of specific genes. a. activators; repressors c. repressors; operators b. activators; enhancers d. repressors; enhancersarrow_forwardThrough alternative splicing, eukaryotes (a) reinforce gene inactivation (b) prevent transcription of heterochromatin (c) produce related but different proteins in different tissues (d) amplify genes to meet the requirement of high levels of a gene product (e) bind transcription factors to enhancers toactivate transcriptionarrow_forwardIn the lac operon, the lac genes are transcribed in the presence of lactose because a RNA polymerase binds to the operator b The repressor can not bind the promoter c Production of the repressor protein is inducible d The inducer binds to the repressor e The inducer binds to the operatorarrow_forward
- Binding of______ to_______ in DNA can increase the rate of transcription of specific genes. a. activators; repressors b. activators; enhancers c. repressors; operators d.repressors; enhancerarrow_forwardYou manipulate the cro and cI/lambda repressor proteins so that they end up with swapped DNA binding domains (cI now has cro’s DNA binding domain, and cro now has cIs). This mutant bacteriophage then infects a happy, healthy population of bacterial cells. How will this modified cro protein interact with the three OR sites, and how would cro expression be affected? Include a drawing if possible.arrow_forwardA scientist identifies a potential transcription regulation site 300bp downstream of a gene and hypothesizes that it is a repressor. What experiment (with results) could he perform to support this hypothesis?arrow_forward
- Regulatory transcription factors can be modulated by a. the binding of small effector molecules. b. protein-protein interactions. c. covalent modifications. d. all of the above.arrow_forwardyou design an ideal promoter for a gene to be highly expressed in E. coli cells? Describe strategies and explainarrow_forwardEukaryotic cells have multiple complex mechanisms for the regulation of gene expression, but a regulatory mechanism they rarely (if ever) use is a. operons. b. regulatory proteins. c. transcriptional factors. d. promoters.arrow_forward
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