(a)
To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.
Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.
Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted
(b)
To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.
Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.
Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.
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EP ORGANIC CHEMISTRY -MOD.MASTERING 18W
- 6. Show how you would carry out the following transformations as shown. More than one step is required in each step. Show all steps clearly with reactants, reagents and products. a. b. OH ? ? OH OHarrow_forwardConvert benzene into attached compound. You may also use any inorganic reagents and organic alcohols having four or fewer carbons. One step of the synthesis must use a Grignard reagent.arrow_forwardWhy does this synthesis fail?arrow_forward
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- Show how to prepare each Gilman reagent from an appropriate alkyl or vinylic halide. Q. 3-Methyloctanearrow_forwardA. Draw the products of the reaction shown below. Use wedge and dish bonds to indicate the dicarbonyl starting material of the reaction shown below. Ignore inorganic stereochemistry. Ignore inorganic byproducts. byproducts. Draw the products resulting from addition of a Grignard reagent to an aldehyde. D. Draw the products resulting from addition of a Grignard reagent to an aldehydom Use a dash or wedge bond to indicate the stereochemistry of substituents on asymmetric centers, where applicablelgnore any inorganic byproducts. Use a dash or wedge bond to indicate the stereochemistry of substituents on asymmetric centers, where applicablelgnore any inorganic byproducts. 1.00 2. NHSO HO 2.HO Select to Draw 1) PhMgCl (CHMgC CH 2) HCI/H:O ++ 1) vinylmagnesium chloride (CH=CHC 2HC/H.O Select to Edit OH Select to Edit Select to Edearrow_forwardBBBarrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage LearningOrganic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning