The Analysis of Biological Data
The Analysis of Biological Data
2nd Edition
ISBN: 9781936221486
Author: Michael C. Whitlock, Dolph Schluter
Publisher: W. H. Freeman
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Red Wine and Weight LossResveratrol, a compound in grapes and red wine, has been shown to promote weight loss in rodents and now in a primate.1 Lemurs fed a resveratrol supplement for four weeks had decreased food intake, increased metabolic rate, and a reduction in seasonal body-mass gain compared to a control group. Suppose a hypothetical study is done for a different primate species, with one group given a resveratrol supplement and the other group given a placebo. We wish to see if there is evidence that resveratrol increases the mean metabolism rate for this species. (This exercise presents hypothetical data. We will see the results from the actual study later in this chapter.)   (a) State the null and alternative hypotheses.Let group 1 be the species taking a resveratrol supplement and let group 2 be the species taking a placebo.
Researchers investigated the possible beneficial effect on heart health of drinking black tea and whether adding milk to the tea reduces any possible benefit. Twenty-four volunteers were randomly assigned to one of three groups. Every day for a month, participants in group 1 drank two cups of hot black tea without milk, participants in group 2 drank two cups of hot black tea with milk, and participants in group 3 drank two cups of hot water but no tea. At the end of the month, the researchers measured the change in each of the participants’ heart health. Did the researchers conduct an experiment or an observational study? Explain.   Why did the researchers include a group who drank hot water but no tea?   Is it reasonable to generalize the results of the study beyond the 24 participants? Explain why or why not.
Researchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.05)   Type II Diabetes No Type II Diabetes Total Investigational Drug 45 19 64 Best standard of Care 70 123 193 Total 115 142 257 Ho? Ha? X2 value? x2 critical? Conclusion?
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