The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene. Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

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Answer 1

Question

Chapter 14, Problem 37ESP

(a)

Summary Introduction

To determine: The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene.

Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

(b)

Summary Introduction

To determine: The reason behind the type of mutation that results in more harmful dysfunction in the translation in mitochondria.

Introduction: The mutation in mitochondrial alanyl-tRNA synthetase is caused by two specific changes in the amino acid. The first change occurs at position 155 from leucine to arginine. The second change occurs at position 592 from arginine to tryptophan.

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What type of mutation is sickle cell anemia? Explain the molecular basis of sickle cell anemia.

Answer 2

Question

Chapter 14, Problem 37ESP

(a)

Summary Introduction

To determine: The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene.

Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

(b)

Summary Introduction

To determine: The reason behind the type of mutation that results in more harmful dysfunction in the translation in mitochondria.

Introduction: The mutation in mitochondrial alanyl-tRNA synthetase is caused by two specific changes in the amino acid. The first change occurs at position 155 from leucine to arginine. The second change occurs at position 592 from arginine to tryptophan.

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Answer 3

Question

Chapter 14, Problem 37ESP

(a)

Summary Introduction

To determine: The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene.

Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

(b)

Summary Introduction

To determine: The reason behind the type of mutation that results in more harmful dysfunction in the translation in mitochondria.

Introduction: The mutation in mitochondrial alanyl-tRNA synthetase is caused by two specific changes in the amino acid. The first change occurs at position 155 from leucine to arginine. The second change occurs at position 592 from arginine to tryptophan.

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Answer 4

Question

Chapter 14, Problem 37ESP

(a)

Summary Introduction

To determine: The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene.

Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

(b)

Summary Introduction

To determine: The reason behind the type of mutation that results in more harmful dysfunction in the translation in mitochondria.

Introduction: The mutation in mitochondrial alanyl-tRNA synthetase is caused by two specific changes in the amino acid. The first change occurs at position 155 from leucine to arginine. The second change occurs at position 592 from arginine to tryptophan.

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Answer 5

Chapter 14, Problem 37ESP

(a)

Summary Introduction

To determine: The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene.

Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

(b)

Summary Introduction

To determine: The reason behind the type of mutation that results in more harmful dysfunction in the translation in mitochondria.

Introduction: The mutation in mitochondrial alanyl-tRNA synthetase is caused by two specific changes in the amino acid. The first change occurs at position 155 from leucine to arginine. The second change occurs at position 592 from arginine to tryptophan.

Answer 6

Chapter 14, Problem 37ESP

(a)

Summary Introduction

To determine: The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene.

Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

Answer 7

Chapter 14, Problem 37ESP

(a)

Summary Introduction

To determine: The prediction that can be made about impaired protein synthesis after the introduction of a missense mutation in the mtAlaRS gene.

Introduction: Infantile cardiomyopathy is a fetal disorder during the first year of life due to the defects in the function of heart muscles. The heart muscles undergo dysfunction due to defects in the function of mitochondria.

Answer 8

(b)

Summary Introduction

To determine: The reason behind the type of mutation that results in more harmful dysfunction in the translation in mitochondria.

Introduction: The mutation in mitochondrial alanyl-tRNA synthetase is caused by two specific changes in the amino acid. The first change occurs at position 155 from leucine to arginine. The second change occurs at position 592 from arginine to tryptophan.

Answer 9

(b)

Summary Introduction

To determine: The reason behind the type of mutation that results in more harmful dysfunction in the translation in mitochondria.

Introduction: The mutation in mitochondrial alanyl-tRNA synthetase is caused by two specific changes in the amino acid. The first change occurs at position 155 from leucine to arginine. The second change occurs at position 592 from arginine to tryptophan.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 14 - Prob. 1NST Ch. 14 - A series of mutations in the bacterium Salmonella...Ch. 14 - HbS results from the substitution of valine for...Ch. 14 - Given that a faulty ribosomal protein is the...Ch. 14 - A couple with a child affected with DBA undergoes...Ch. 14 - Prob. 3CS Ch. 14 - HOW DO WE KNOW? In this chapter, we focused on the...Ch. 14 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 14 - Contrast the roles of tRNA and mRNA during...Ch. 14 - Francis Crick proposed the adaptor hypothesis for...

Solution Summary: The author explains that a missense mutation in the mitochondrial alanyl-tRNA synthetase (mtAlaRS) affects the mRNA translation because it plays an important role in charging

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