Biology: How Life Works
3rd Edition
ISBN: 9781319017637
Author: James Morris, Daniel Hartl, Andrew Knoll, Melissa Michael, Robert Lue, Andrew Berry, Andrew Biewener, Brian Farrell, N. Michele Holbrook
Publisher: Macmillan Higher Education
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Chapter 14.5, Problem 15SAQ
Summary Introduction
DNA (genetic material) carries genetic information from mother to offspring in both prokaryotes and eukaryotes. As it is fragile, it prone to various genetic damages. A change in the DNA sequence of the cell is known as a mutation. Mutations often occur in two ways such as spontaneous mutations (which arise occasionally) and induced mutations (which arise from the exposure of mutagens). Mutations affect the
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What are the essential differences between base excision repair and nucleotide excision repair and what types of DNA damage are they dedicated to repairing?
What is nucleotide excision repair? What kind of DNA damage does it target for repair?
What are DNA excision-repair systems?
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- How is mismatch repair different from excision repair (in terms of what type of mutation it is used for and how the events proceed)?arrow_forwardWhat is an advantage and a disadvantage of this repair system?arrow_forward1.Photoreactivation is called a direct reversal of DNA damage. Mismatch repair, Nucleotide excision repair and base excision repair correct DNA mismatches and damaged bases, but these systems are not considered direct repair. what two general steps do these indirect repair systems have in common?.arrow_forward
- Which repair pathway recognizes DNA damage duringtranscription? What happens if the damage is notrepaired?arrow_forward7.25 Describe, base-excision repair, light repair of pyrimidine dimers, nucleotide-excision repair, mismatch repair, and error-prone repair, such as the SOS response.arrow_forwardHow would nucleotide excision repair be affected if one of the followingproteins was missing? Describe the condition of the DNAif the repair was attempted in the absence of the protein.A. UvrAB. UvrCC. UvrDD. DNA polymerasearrow_forward
- Explain why base excision repair, nucleotide excision repair, and mismatch repair—which all require nucleases to excise damaged DNA—require DNA ligase.arrow_forwardThere are two types of excision repair, base excision repair (BER) and nucleotide excision repair (NER). Which enzymes are used in Base excision repair in E. coli?And In nucleotide excision repair, what kind of damage is repaired by this mechanism and why are cutsmade on both sides of the damaged region of DNA?arrow_forwardWhat do you mean by Repair of a Collapsed Replication Fork ?arrow_forward
- Define the mechanism of Nucleotide Excision Repair in eukaryotes ?arrow_forwardWhat is meant by “error-prone” DNA repair?arrow_forwardAll of these DNA-repair mechanisms use an undamaged complementary DNA strand as a template for replacing the excised nucleotides EXCEPT for____ base-excision repair. homologous recombination. mismatch repair. nonhomologous end joining. nucleotide-excision repairarrow_forward
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