Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134145815
Author: KLUG
Publisher: PEARSON
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Textbook Question
Chapter 15, Problem 12PDQ
Predict the effect on the inducibility of the lac operon of a mutation that disrupts the function of (a) the crp gene, which encodes the CAP protein, and (b) the CAP-binding site within the promoter.
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Predict the effect on the inducibility of the lac operon of a mutation that disrupts the function of (a) the crp gene, which encodes the CAP protein, and (b) the CAP-binding site within the promoter.
Explain why catabolite repression is used in regulating the lac operon and describe how it fine-tunes b-galactosidase synthesis.
Mutation in the regulatory gene in the lac operon results in the formation of an inactive repressor. List and explain the effect of such a mutation on the expression of the structural gene for lactose in E.coli?
Chapter 15 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 15 -
CASE STUDY | A mysterious muscular dystrophy
A...Ch. 15 -
CASE STUDY |A mysterious muscular dystrophy
A...Ch. 15 -
CASE STUDY |A mysterious muscular dystrophy
A...Ch. 15 -
HOW DO WE KNOW?
1. In this chapter, we have...Ch. 15 -
2. Review the Chapter Concepts list on p. 280....Ch. 15 - Describe which enzymes are required for lactose...Ch. 15 - Contrast positive versus negative regulation of...Ch. 15 -
5. Both attenuation and riboswitches rely on...Ch. 15 - For the lac genotypes shown in the accompanying...Ch. 15 -
7. For the genotypes and conditions (lactose...
Ch. 15 -
8. The locations of numerous lacI– and lacIs...Ch. 15 - Explain why catabolite repression is used in...Ch. 15 - Describe experiments that would confirm whether or...Ch. 15 - Predict the level of genetic activity of the lac...Ch. 15 - Predict the effect on the inducibility of the lac...Ch. 15 -
13. Describe the role of attenuation in the...Ch. 15 -
14. In a theoretical operon, genes A, B, C, and D...Ch. 15 - A bacterial operon is responsible for production...Ch. 15 - A marine bacterium is isolated and is shown to...Ch. 15 -
17. Why is gene regulation more complex in a...Ch. 15 -
18. List and define the levels of eukaryotic gene...Ch. 15 -
19. Distinguish between the cis-acting regulatory...Ch. 15 - Prob. 20PDQCh. 15 - Compare the control of gene regulation in...Ch. 15 - Many eukaryotic promoter regions contain CAAT...Ch. 15 -
23. What is RNA-induced gene silencing in...Ch. 15 - Although it is customary to consider...Ch. 15 - DNA methylation is commonly associated with a...Ch. 15 - The interphase nucleus appears to be a highly...Ch. 15 - It has been estimated that at least two-thirds of...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- PREDICT Compare the types of bacterial genes associated with inducible operons, those associated with repressible operons, and those that are constitutive. Predict the category into which each of the following would most likely fit: (a) a gene that codes for RNA polymerase, (b) a gene that codes for an enzyme required to break down maltose, and (c) a gene that codes for an enzyme used in the synthesis of adenine.arrow_forwardExplain the role of CAP and cAMP in the regulation of the lac-operon.arrow_forwardIf β-galactosidase is expressed when lactose is absent, what does this suggest about the lac operon? a) There is a mutation in the repressor protein b) There is a mutation in the catabolite activator protein c) There is a mutation in the promoter region d) There is a mutation in the luxI proteinarrow_forward
- Describe a bacterial operon's structural advantage. Explain transcriptional stages such as initiation, elongation, and termination. In this article, please explain on the involvement of the sigma factor, elongation processes, and attenuation.arrow_forwardUsing the lac operon as a model, explain the role of inducers, repressors, and inducer exclusion.arrow_forwardDescribe the regulation of the lac operon when lactose is present and glucose is absentarrow_forward
- Describe the binding of RNA polymerase, repressors, andactivators to the lac operon when both lactose and glucose are scarce. What is the effect of these scarcities ontranscription of the lac operon?arrow_forwardIn the lac operon (below), how will expression of the genes lacZ and lacy be effect by a mutation in the repressor protein (encoded by lach) that prevents it from binding the operator sequence (lacO) in the absence of lactose? Explain the answerarrow_forwardExplain how the data shown indicate that two operator sites are necessary for repression of the lac operon. What would the results have been if all three operator sites were required for the binding of lac repressor?arrow_forward
- Diagram the lactose operon in E. coli with the properorder of the elements lacI, lacO, lacY, and lacZ, and explainhow expression is controlled in the presence and in theabsence of lactose.arrow_forwardDescribe the role of the CRP–cAMP complex in positiveregulation of the lactose operon in E. coli.arrow_forwardThe TRP operon functions by attenuation. Briefly explain how attenuation works and why it is necessary, in addition to the repressor protein, in regulating the operon.arrow_forward
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