Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134145815
Author: KLUG
Publisher: PEARSON
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Textbook Question
Chapter 15, Problem 1PDQ
HOW DO WE KNOW?
In this chapter, we have focused on how prokaryotic and eukaryotic organisms regulate the expression of genetic information. In particular, we discussed both transcriptional and posttranscriptional gene regulation. Based on your knowledge of these topics, answer several fundamental questions:
(a) How do we know that bacteria regulate the expression of certain genes in response to the environment?
(b) How do we know that bacterial gene clusters are often coordinately regulated by a regulatory region that must be located adjacent to the cluster?
(c) What led researchers to conclude that a trans-acting repressor molecule regulates the lac operon?
(d) How do we know that promoters and enhancers regulate transcription of eukaryotic genes?
(e) How do we know that DNA methylation plays a role in the regulation of eukaryotic gene expression?
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Compare the control of gene regulation in eukaryotes and prokaryotes at the level of initiation of transcription. How do the regulatory mechanisms work? What are the similarities and differences in these two types of organisms in terms of the specific components of the regulatory mechanisms? Address how the differences or similarities relate to the biological context of the control of gene expression.
name TWO mechanisms of control of gene expression that are only used by eukaryotes and discuss why each of those mechanisms wouldn’t be possible in prokaryotes.
You are teaching a class on the regulation of eukaryotic gene expression. In order to demonstrate this complex process, you decide to draw for the class a typical eukaryotic gene/transcription unit with its major regions, such as the promoter regions, where the RNA polymerase II and transcription factors would bind
From the list given - choose all components that you think are part of a typical eukaryotic gene
From the list given - choose all the regulatory sequences that you think would control the expression of this eukaryotic gene
From the list given - choose all of the regulatory proteins that would bind the eukaryotic gene to control its expression
Chapter 15 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 15 -
CASE STUDY | A mysterious muscular dystrophy
A...Ch. 15 -
CASE STUDY |A mysterious muscular dystrophy
A...Ch. 15 -
CASE STUDY |A mysterious muscular dystrophy
A...Ch. 15 -
HOW DO WE KNOW?
1. In this chapter, we have...Ch. 15 -
2. Review the Chapter Concepts list on p. 280....Ch. 15 - Describe which enzymes are required for lactose...Ch. 15 - Contrast positive versus negative regulation of...Ch. 15 -
5. Both attenuation and riboswitches rely on...Ch. 15 - For the lac genotypes shown in the accompanying...Ch. 15 -
7. For the genotypes and conditions (lactose...
Ch. 15 -
8. The locations of numerous lacI– and lacIs...Ch. 15 - Explain why catabolite repression is used in...Ch. 15 - Describe experiments that would confirm whether or...Ch. 15 - Predict the level of genetic activity of the lac...Ch. 15 - Predict the effect on the inducibility of the lac...Ch. 15 -
13. Describe the role of attenuation in the...Ch. 15 -
14. In a theoretical operon, genes A, B, C, and D...Ch. 15 - A bacterial operon is responsible for production...Ch. 15 - A marine bacterium is isolated and is shown to...Ch. 15 -
17. Why is gene regulation more complex in a...Ch. 15 -
18. List and define the levels of eukaryotic gene...Ch. 15 -
19. Distinguish between the cis-acting regulatory...Ch. 15 - Prob. 20PDQCh. 15 - Compare the control of gene regulation in...Ch. 15 - Many eukaryotic promoter regions contain CAAT...Ch. 15 -
23. What is RNA-induced gene silencing in...Ch. 15 - Although it is customary to consider...Ch. 15 - DNA methylation is commonly associated with a...Ch. 15 - The interphase nucleus appears to be a highly...Ch. 15 - It has been estimated that at least two-thirds of...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The most common type of regulation of gene expression occurs at the level of transcription. Name other types of gene regulation for gene expression in eukaryotic cells. Name types of gene regulation unique to eukaryotic cells versus prokaryotic cells.arrow_forwardGiven the following schematic for a gene and its associated regulatory regions, answer the following questions by placing the correct letter in the provided blanks please put in the correct letter for the questions What region would provide cell type-specific expression of genes? region What site would significantly increase gene expression rates? = region What region or regions of this gene’s coding sequence are expressed as amino acids = regionarrow_forwardPlease answer both questions Explain five ways that eukaryotic gene regulation is more complex than bacterial gene regulation? Mutations in the promoter region of the B-globin gene indicate that some areas are more sensitive than others. When mutations occur in consensus sequences(modular elements such as GC box, CAAT box, and TATA box), does transcription usually increase or decrease? Explain.arrow_forward
- A crucial step in the regulation of many bacterial genes is the binding of RNA polymerase to DNA at the promoter. Why might it be advantageous for bacteria to regulate the expression of their genes at this particular step?arrow_forwardEukaryotes have a multitude of ways of regulating gene expression. Why are all these regulatory mechanisms necessary to the functioning of a eukaryotic organism?arrow_forwardwhat novel mechanisms not yet found, are involved in the gene regulation?arrow_forward
- In response to potentially toxic substances (e.g., high levels of iron), eukaryotic cells often use translational or posttranslational regulatory mechanisms to prevent cell death, rather than using transcriptional regulatory mechanisms. Explain why.arrow_forwardProvide a detailed description of gene expression and control in prokaryotes. Provide a detailed description of proteins critical for this process. (please hand draw a figure showing gene expression and control in prokaryotes and the proteins involved)arrow_forwardWhile investigating the function of a specific growth factor receptor gene from humans, researchers found that two types of proteins are synthesized from this gene. A larger protein containing a membrane spanning domain recognizes growth factors at the cell surface, stimulating a specific downstream signaling pathway. In contrast, a related, smaller protein is secreted from the cell and binds available growth factor circulating in the blood, thus inhibiting the downstream signaling pathway. Speculate on how the cell synthesizes these disparate proteins.arrow_forward
- If you were given a tube containing only a purified protein of interest but had unlimited time and resources, how would you determine the in vivo expression levels of that protein? Is there another level of regulation beyond the protein expression level which might not be observable with the method you described?arrow_forwardWhat are the functions of transcriptional activator proteins and repressor proteins? Explain how they work at the molecular level.arrow_forwardMethylation of H3K9 by itself silences genes, but if H3K4 and H4K20 are also methylated, the combination of modifications stimulates transcription. What conclusions can you draw about this?arrow_forward
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