Chapter 15, Problem 15P

Summary Introduction

To propose: The specific types of mutations in the gene for the regulatory subunit of cyclic-AMP-dependent protein kinase (PKA) that could lead to either a permanently active PKA or a permanently inactive PKA.

Introduction:

In some cell signaling pathways, cyclic AMP (cAMP) act as second messengers and show their effect by activating cyclic-AMP-dependent protein kinase (PKA). Inactive PKA is composed of two regulatory and two catalytic subunits. When cAMP binds to the regulatory subunits, they get dissociated from PKA complex. The catalytic subunits of PKA that are released activate and phosphorylate specific target proteins for their regulation.